BAIT
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
GO Process (70)
GO Function (26)
GO Component (25)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- adult locomotory behavior [ISO]
- aging [IEP]
- behavioral response to cocaine [IMP]
- calcium ion homeostasis [ISO]
- cellular response to copper ion [ISO]
- cellular response to fibroblast growth factor stimulus [IEP]
- cellular response to oxidative stress [ISO]
- dopamine biosynthetic process [ISO]
- dopamine metabolic process [ISO]
- fatty acid metabolic process [ISO]
- long-term synaptic potentiation [ISO]
- membrane organization [ISO]
- microglial cell activation [ISO]
- mitochondrial ATP synthesis coupled electron transport [ISO]
- mitochondrial membrane organization [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of dopamine metabolic process [IMP]
- negative regulation of dopamine uptake involved in synaptic transmission [ISO]
- negative regulation of exocytosis [ISO]
- negative regulation of histone acetylation [ISO]
- negative regulation of microtubule polymerization [ISO]
- negative regulation of monooxygenase activity [ISO]
- negative regulation of neuron apoptotic process [IMP, ISO]
- negative regulation of norepinephrine uptake [ISO]
- negative regulation of platelet-derived growth factor receptor signaling pathway [ISO]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of serotonin uptake [ISO]
- negative regulation of thrombin receptor signaling pathway [ISO]
- negative regulation of transporter activity [ISO]
- neutral lipid metabolic process [ISO]
- oxidation-reduction process [ISO]
- phospholipid metabolic process [ISO]
- positive regulation of endocytosis [ISO]
- positive regulation of glutathione peroxidase activity [ISO]
- positive regulation of hydrogen peroxide catabolic process [ISO]
- positive regulation of inositol phosphate biosynthetic process [ISO]
- positive regulation of neurotransmitter secretion [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of protein serine/threonine kinase activity [ISO]
- positive regulation of receptor recycling [ISO]
- positive regulation of release of sequestered calcium ion into cytosol [ISO]
- positive regulation of synaptic transmission [ISO]
- protein destabilization [ISO]
- receptor internalization [ISO]
- regulation of acyl-CoA biosynthetic process [ISO]
- regulation of dopamine secretion [ISO]
- regulation of excitatory postsynaptic membrane potential [ISO]
- regulation of glutamate secretion [ISO]
- regulation of locomotion [ISO]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of macrophage activation [ISO]
- regulation of neuron apoptotic process [ISO]
- regulation of neuron death [IGI]
- regulation of neuronal synaptic plasticity [ISO]
- regulation of neurotransmitter secretion [ISO]
- regulation of phospholipase activity [ISO]
- response to cocaine [IEP]
- response to drug [ISO]
- response to interferon-gamma [ISO]
- response to interleukin-1 [ISO]
- response to iron(II) ion [ISO]
- response to lipopolysaccharide [ISO]
- response to magnesium ion [ISO]
- synapse organization [ISO]
- synaptic transmission [ISO]
- synaptic transmission, dopaminergic [ISO]
- synaptic vesicle endocytosis [ISO]
- synaptic vesicle transport [ISO]
Gene Ontology Molecular Function- Hsp70 protein binding [ISO]
- alpha-tubulin binding [ISO]
- arachidonic acid binding [ISO]
- beta-tubulin binding [IDA]
- calcium ion binding [ISO]
- copper ion binding [ISO, ISS]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- dynein binding [ISO]
- enzyme binding [IPI]
- fatty acid binding [ISO]
- ferrous iron binding [ISO]
- histone binding [ISO]
- identical protein binding [ISO]
- kinesin binding [ISO]
- magnesium ion binding [ISO]
- microtubule binding [IDA]
- oxidoreductase activity [ISO]
- phospholipase D inhibitor activity [ISO]
- phospholipase binding [IPI]
- phospholipid binding [IDA, ISO]
- phosphoprotein binding [ISO]
- protein N-terminus binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- tau protein binding [ISO]
- zinc ion binding [ISO]
- Hsp70 protein binding [ISO]
- alpha-tubulin binding [ISO]
- arachidonic acid binding [ISO]
- beta-tubulin binding [IDA]
- calcium ion binding [ISO]
- copper ion binding [ISO, ISS]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]
- dynein binding [ISO]
- enzyme binding [IPI]
- fatty acid binding [ISO]
- ferrous iron binding [ISO]
- histone binding [ISO]
- identical protein binding [ISO]
- kinesin binding [ISO]
- magnesium ion binding [ISO]
- microtubule binding [IDA]
- oxidoreductase activity [ISO]
- phospholipase D inhibitor activity [ISO]
- phospholipase binding [IPI]
- phospholipid binding [IDA, ISO]
- phosphoprotein binding [ISO]
- protein N-terminus binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- tau protein binding [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- actin cytoskeleton [ISO]
- axon [ISO]
- axon terminus [IDA]
- cell [ISO]
- cell cortex [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic vesicle membrane [IDA]
- cytoskeleton [ISO]
- cytosol [IDA, ISO]
- fibril [ISO]
- growth cone [IDA, ISO]
- inclusion body [ISO]
- intracellular membrane-bounded organelle [IDA]
- mitochondrion [IDA, ISO]
- nuclear outer membrane [IDA]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- platelet alpha granule membrane [ISO]
- ribosome [IDA]
- rough endoplasmic reticulum [IDA]
- synapse [ISO]
- synaptic vesicle [IDA]
- terminal bouton [IDA]
Rattus norvegicus
PREY
TOMM20
translocase of outer mitochondrial membrane 20 homolog (yeast)
GO Process (2)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
?-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease.
?-Synuclein accumulation and mitochondrial dysfunction have both been strongly implicated in the pathogenesis of Parkinson's disease (PD), and the two appear to be related. Mitochondrial dysfunction leads to accumulation and oligomerization of ?-synuclein, and increased levels of ?-synuclein cause mitochondrial impairment, but the basis for this bidirectional interaction remains obscure. We now report that certain posttranslationally modified species of ?-synuclein ... [more]
Sci Transl Med Dec. 08, 2015; 8(342);342ra78 [Pubmed: 27280685]
Throughput
- Low Throughput
Additional Notes
- PLA
Curated By
- BioGRID