CNR2
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- cannabinoid signaling pathway [ISO]
- negative regulation of action potential [ISO]
- negative regulation of inflammatory response [ISO]
- negative regulation of mast cell activation [ISO]
- negative regulation of nitric-oxide synthase activity [ISO]
- negative regulation of synaptic transmission, GABAergic [ISO]
- response to lipopolysaccharide [ISO]
- sensory perception of pain [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RELN
Gene Ontology Biological Process
- N-methyl-D-aspartate receptor clustering [IMP]
- associative learning [IDA]
- axon guidance [IMP]
- brain development [IMP, ISO]
- cell migration [IMP]
- cell morphogenesis involved in differentiation [IMP]
- central nervous system development [IMP]
- cerebral cortex development [IMP]
- cerebral cortex tangential migration [IMP]
- dendrite development [IGI, IMP]
- dentate gyrus development [ISO]
- forebrain development [IMP]
- glial cell differentiation [IMP]
- hippocampus development [IDA]
- lateral motor column neuron migration [IMP]
- layer formation in cerebral cortex [IMP]
- locomotory behavior [IMP, ISO]
- long-term memory [IDA]
- neuron migration [IGI, IMP, ISO]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of CREB transcription factor activity [IDA]
- positive regulation of TOR signaling [IDA]
- positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IDA]
- positive regulation of dendritic spine morphogenesis [IDA, IMP]
- positive regulation of excitatory postsynaptic membrane potential [IDA, IMP]
- positive regulation of lateral motor column neuron migration [IMP]
- positive regulation of long-term synaptic potentiation [IDA]
- positive regulation of neuron projection development [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein kinase activity [IDA, IGI]
- positive regulation of protein tyrosine kinase activity [IDA]
- positive regulation of small GTPase mediated signal transduction [IDA]
- positive regulation of synapse maturation [IDA]
- positive regulation of synaptic transmission, glutamatergic [IDA, IMP]
- postsynaptic density assembly [IC]
- postsynaptic density protein 95 clustering [IMP]
- protein localization to synapse [IMP]
- receptor localization to synapse [IMP]
- reelin-mediated signaling pathway [IDA]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [IMP]
- regulation of behavior [IMP]
- regulation of gene expression [IMP]
- regulation of synaptic transmission [IMP]
- response to pain [IMP]
- spinal cord patterning [IMP]
- thyroid hormone metabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Proteins of the CNR family are multiple receptors for Reelin.
Layering and positioning of neurons require Reelin- and Src family-associated mammalian Disabled (mDab1). Cadherin-related neuronal receptor (CNR) genes are expressed in neurons of the cortical layer, but not in Cajal-Retzius cells expressing Reelin. This leads us to hypothesize that CNRs bound to Fyn of the Src family are receptors for Reelin. Herein we confirm the association and colocalization of CNR ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID