BAIT
NR3C1
GCCR, GCR, GCRST, GR, GRL
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
GO Process (8)
GO Function (8)
GO Component (4)
Gene Ontology Biological Process
- cellular response to steroid hormone stimulus [IDA]
- gene expression [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA]
- signal transduction [TAS]
- transcription from RNA polymerase II promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- glucocorticoid receptor activity [TAS]
- glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- steroid binding [IDA]
- steroid hormone binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- glucocorticoid receptor activity [TAS]
- glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- steroid binding [IDA]
- steroid hormone binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
MEGF8
C19orf49, CRPT2, EGFL4, SBP1
multiple EGF-like-domains 8
GO Process (15)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- BMP signaling pathway [ISS]
- cell migration involved in gastrulation [IMP]
- craniofacial suture morphogenesis [IMP]
- determination of digestive tract left/right asymmetry [ISS]
- determination of heart left/right asymmetry [IMP]
- embryonic heart tube left/right pattern formation [ISS]
- embryonic heart tube morphogenesis [ISS]
- embryonic limb morphogenesis [ISS]
- embryonic skeletal system morphogenesis [ISS]
- epiboly involved in gastrulation with mouth forming second [IMP]
- fasciculation of sensory neuron axon [ISS]
- left/right pattern formation [IMP]
- limb morphogenesis [IMP]
- positive regulation of axon extension involved in axon guidance [ISS]
- regulation of gene expression [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
TNF-? inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.
Glucocorticoid resistance (GCR) is defined as an unresponsiveness to the therapeutic effects, including the antiinflammatory ones of glucocorticoids (GCs) and their receptor, the glucocorticoid receptor (GR). It is a problem in the management of inflammatory diseases and can be congenital as well as acquired. The strong proinflammatory cytokine TNF-alpha (TNF) induces an acute form of GCR, not only in mice, ... [more]
Proc Natl Acad Sci U S A Dec. 25, 2018; 116(26);12942-12951 [Pubmed: 31182584]
Throughput
- High Throughput
Curated By
- BioGRID