BAIT
NR3C1
GCCR, GCR, GCRST, GR, GRL
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
GO Process (8)
GO Function (8)
GO Component (4)
Gene Ontology Biological Process
- cellular response to steroid hormone stimulus [IDA]
- gene expression [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA]
- signal transduction [TAS]
- transcription from RNA polymerase II promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- glucocorticoid receptor activity [TAS]
- glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- steroid binding [IDA]
- steroid hormone binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- glucocorticoid receptor activity [TAS]
- glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- steroid binding [IDA]
- steroid hormone binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
RAB3GAP1
P130, RAB3GAP, RAB3GAP130, WARBM1
RAB3 GTPase activating protein subunit 1 (catalytic)
GO Process (14)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- brain development [IMP]
- camera-type eye development [IMP]
- establishment of protein localization to endoplasmic reticulum membrane [IMP]
- face morphogenesis [IMP]
- hypothalamus development [IMP]
- lipid particle organization [IMP]
- positive regulation of GTP catabolic process [IMP]
- positive regulation of Rab GTPase activity [IMP, ISS]
- positive regulation of endoplasmic reticulum tubular network organization [IMP]
- positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization [ISS]
- regulation of GTPase activity [IDA]
- regulation of calcium ion-dependent exocytosis of neurotransmitter [ISS]
- regulation of excitatory postsynaptic membrane potential [ISS]
- regulation of short-term neuronal synaptic plasticity [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
TNF-? inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.
Glucocorticoid resistance (GCR) is defined as an unresponsiveness to the therapeutic effects, including the antiinflammatory ones of glucocorticoids (GCs) and their receptor, the glucocorticoid receptor (GR). It is a problem in the management of inflammatory diseases and can be congenital as well as acquired. The strong proinflammatory cytokine TNF-alpha (TNF) induces an acute form of GCR, not only in mice, ... [more]
Proc Natl Acad Sci U S A Dec. 25, 2018; 116(26);12942-12951 [Pubmed: 31182584]
Throughput
- High Throughput
Curated By
- BioGRID