BAIT

NR3C1

GCCR, GCR, GCRST, GR, GRL

nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

Alzheimer's Disease Project

GO Process (8)

GO Function (8)

GO Component (4)

Gene Ontology Biological Process

cellular response to steroid hormone stimulus [IDA]

gene expression [TAS]

positive regulation of transcription from RNA polymerase II promoter [IDA]

regulation of transcription, DNA-templated [IDA]

signal transduction [TAS]

transcription from RNA polymerase II promoter [TAS]

transcription initiation from RNA polymerase II promoter [TAS]

transcription, DNA-templated [TAS]

Gene Ontology Molecular Function

RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
glucocorticoid receptor activity [TAS]
glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity [IDA]
protein binding [IPI]
sequence-specific DNA binding transcription factor activity [IDA]
steroid binding [IDA]
steroid hormone binding [IDA]

Gene Ontology Cellular Component

cytoplasm [IDA]

mitochondrial matrix [TAS]

nucleoplasm [IDA, TAS]

CRISPR Database OMIM VEGA HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

ZNF281

ZBP-99, ZNP-99

zinc finger protein 281

GO Process (6)

GO Function (8)

GO Component (2)

Gene Ontology Biological Process

embryonic body morphogenesis [ISS]

negative regulation of gene expression [IDA, IMP]

negative regulation of transcription from RNA polymerase II promoter [IDA]

negative regulation of transcription, DNA-templated [IDA, IMP]

positive regulation of transcription, DNA-templated [IDA]

stem cell differentiation [ISS]

Gene Ontology Molecular Function

RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
core promoter binding [ISS]
protein binding [IPI]
sequence-specific DNA binding [IDA]
sequence-specific DNA binding transcription factor activity [IDA]
transcription corepressor activity [ISS]
transcription regulatory region DNA binding [IDA]

Gene Ontology Cellular Component

nucleoplasm [IDA]

CRISPR Database VEGA HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Proximity Label-MS

An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.

Publication

TNF-? inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

Dendoncker K, Timmermans S, Vandewalle J, Eggermont M, Lempiaeinen J, Paakinaho V, Van Hamme E, Dewaele S, Vandevyver S, Ballegeer M, Souffriau J, Van Wyngene L, Van Looveren K, Vanderhaeghen T, Beyaert R, De Bosscher K, Palvimo JJ, Van Montagu M, Libert C

Glucocorticoid resistance (GCR) is defined as an unresponsiveness to the therapeutic effects, including the antiinflammatory ones of glucocorticoids (GCs) and their receptor, the glucocorticoid receptor (GR). It is a problem in the management of inflammatory diseases and can be congenital as well as acquired. The strong proinflammatory cytokine TNF-alpha (TNF) induces an acute form of GCR, not only in mice, ... [more]

Proc Natl Acad Sci U S A Dec. 25, 2018; 116(26);12942-12951 [Pubmed: 31182584]

Throughput

High Throughput

Curated By

BioGRID