BAIT
NR3C1
GCCR, GCR, GCRST, GR, GRL
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
GO Process (8)
GO Function (8)
GO Component (4)
Gene Ontology Biological Process
- cellular response to steroid hormone stimulus [IDA]
- gene expression [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [IDA]
- signal transduction [TAS]
- transcription from RNA polymerase II promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- glucocorticoid receptor activity [TAS]
- glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- steroid binding [IDA]
- steroid hormone binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- glucocorticoid receptor activity [TAS]
- glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- steroid binding [IDA]
- steroid hormone binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
IRAK3
ASRT5, IRAKM
interleukin-1 receptor-associated kinase 3
GO Process (24)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- cytokine-mediated signaling pathway [ISS]
- interleukin-1-mediated signaling pathway [IMP]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of cytokine-mediated signaling pathway [IC]
- negative regulation of innate immune response [ISS]
- negative regulation of interleukin-12 production [IMP, ISS]
- negative regulation of interleukin-6 production [IMP, ISS]
- negative regulation of macrophage cytokine production [ISS]
- negative regulation of protein catabolic process [IMP]
- negative regulation of protein complex disassembly [IMP]
- negative regulation of toll-like receptor signaling pathway [ISS]
- negative regulation of tumor necrosis factor production [IMP]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of macrophage tolerance induction [ISS]
- protein phosphorylation [IDA]
- regulation of protein complex disassembly [ISS]
- response to exogenous dsRNA [ISS]
- response to interleukin-1 [IMP]
- response to lipopolysaccharide [ISS]
- response to peptidoglycan [ISS]
- response to virus [IC]
- toll-like receptor signaling pathway [IBA]
Gene Ontology Molecular Function
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
TNF-? inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.
Glucocorticoid resistance (GCR) is defined as an unresponsiveness to the therapeutic effects, including the antiinflammatory ones of glucocorticoids (GCs) and their receptor, the glucocorticoid receptor (GR). It is a problem in the management of inflammatory diseases and can be congenital as well as acquired. The strong proinflammatory cytokine TNF-alpha (TNF) induces an acute form of GCR, not only in mice, ... [more]
Proc Natl Acad Sci U S A Dec. 25, 2018; 116(26);12942-12951 [Pubmed: 31182584]
Throughput
- High Throughput
Curated By
- BioGRID