BAIT
DPYSL3
Crmp4, TUC-4b
dihydropyrimidinase-like 3
GO Process (11)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- actin crosslink formation [IDA]
- actin filament bundle assembly [IDA]
- cellular response to cytokine stimulus [IEP]
- negative regulation of cell migration [IMP]
- negative regulation of neuron projection development [IMP]
- nervous system development [ISO]
- neuron development [IEP]
- positive regulation of filopodium assembly [IDA]
- positive regulation of neuron projection development [IDA]
- protein homooligomerization [IDA]
- response to axon injury [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
ACTB
Actx
actin, beta
GO Process (7)
GO Function (8)
GO Component (16)
Gene Ontology Biological Process
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- Tat protein binding [ISO]
- kinesin binding [ISO]
- nitric-oxide synthase binding [ISO]
- nucleosomal DNA binding [ISO]
- protein binding [IPI]
- protein kinase binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [ISO]
- Tat protein binding [ISO]
- kinesin binding [ISO]
- nitric-oxide synthase binding [ISO]
- nucleosomal DNA binding [ISO]
- protein binding [IPI]
- protein kinase binding [IPI]
Gene Ontology Cellular Component
- MLL5-L complex [ISO]
- NuA4 histone acetyltransferase complex [ISO]
- axon [IDA]
- blood microparticle [ISO]
- cortical cytoskeleton [ISO]
- cytoplasmic ribonucleoprotein granule [ISO]
- cytosol [ISO, TAS]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- membrane [ISO]
- myelin sheath [ISO]
- nuclear chromatin [ISO]
- postsynaptic density [IDA]
- protein complex [IDA, ISO]
- ribonucleoprotein complex [ISO]
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
CRMP4 regulates dendritic growth and maturation via the interaction with actin cytoskeleton in cultured hippocampal neurons.
CRMP family proteins (CRMPs) are critical for neurite outgrowth and maturation in the developing nervous system. However, the distinct roles of CRMP isoforms remain to be elucidated, especially in dendritic development. Here, we show that CRMP4 is sufficient and necessary for dendritic growth and maturation in cultured hippocampal neurons. Overexpression of CRMP4 promotes and genetic knockdown of CRMP4 inhibits the ... [more]
Brain Res Bull Dec. 01, 2015; 124();286-94 [Pubmed: 27339813]
Throughput
- Low Throughput
Curated By
- BioGRID