BAIT
NRP1
Nrp
neuropilin 1
GO Process (55)
GO Function (5)
GO Component (12)
Gene Ontology Biological Process
- VEGF-activated neuropilin signaling pathway [ISO]
- VEGF-activated neuropilin signaling pathway involved in axon guidance [ISO]
- angiogenesis [ISO]
- angiogenesis involved in coronary vascular morphogenesis [ISO]
- artery morphogenesis [ISO]
- axon extension involved in axon guidance [ISO]
- axon guidance [IMP, ISO]
- axonal fasciculation [ISO]
- axonogenesis involved in innervation [ISO]
- cell migration [ISO]
- cell migration involved in sprouting angiogenesis [ISO]
- cellular response to hepatocyte growth factor stimulus [ISO]
- cellular response to vascular endothelial growth factor stimulus [ISO]
- commissural neuron axon guidance [ISO]
- coronary artery morphogenesis [ISO]
- dendrite development [ISO]
- dichotomous subdivision of terminal units involved in salivary gland branching [ISO]
- endothelial cell chemotaxis [ISO]
- gonadotrophin-releasing hormone neuronal migration to the hypothalamus [ISO]
- heart development [ISO]
- hepatocyte growth factor receptor signaling pathway [ISO]
- negative regulation of axon extension [ISO]
- negative regulation of axon extension involved in axon guidance [IMP, ISO]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- negative regulation of neuron apoptotic process [ISO]
- nerve development [ISO]
- nervous system development [NAS]
- neural crest cell migration involved in autonomic nervous system development [ISO]
- neuron development [ISO]
- neuron migration [ISO]
- patterning of blood vessels [ISO]
- peptidyl-tyrosine phosphorylation [ISO]
- platelet-derived growth factor receptor signaling pathway [ISO]
- positive chemotaxis [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of axon extension involved in axon guidance [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of retinal ganglion cell axon guidance [ISO]
- protein localization to early endosome [ISO]
- regulation of axon extension involved in axon guidance [ISO]
- regulation of retinal ganglion cell axon guidance [ISO]
- renal artery morphogenesis [ISO]
- response to wounding [IEP]
- retina vasculature morphogenesis in camera-type eye [ISO]
- retinal ganglion cell axon guidance [ISO]
- semaphorin-plexin signaling pathway [ISO]
- semaphorin-plexin signaling pathway involved in neuron projection guidance [ISO]
- sprouting angiogenesis [ISO]
- sympathetic ganglion development [ISO]
- sympathetic nervous system development [ISO]
- sympathetic neuron projection extension [ISO]
- sympathetic neuron projection guidance [ISO]
- toxin transport [ISO]
- trigeminal nerve morphogenesis [ISO]
- vascular endothelial growth factor receptor signaling pathway [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
GDNF
gndf
glial cell derived neurotrophic factor
GO Process (33)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- branching involved in ureteric bud morphogenesis [ISO, ISS]
- cell proliferation [IDA]
- cellular response to dexamethasone stimulus [IDA]
- enteric nervous system development [ISO, ISS]
- mRNA stabilization [ISO, ISS]
- male gonad development [IEP]
- mesenchymal to epithelial transition involved in metanephros morphogenesis [IDA]
- metanephros development [ISO, ISS]
- midbrain development [IEP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of neuron apoptotic process [ISO, ISS]
- nervous system development [ISO, TAS]
- neural crest cell migration [ISO, ISS]
- neuron differentiation [IDA]
- neuron projection development [ISO, ISS]
- organ induction [ISO]
- peripheral nervous system development [ISO]
- peristalsis [ISO, ISS]
- positive regulation of branching involved in ureteric bud morphogenesis [IDA, IMP, ISO]
- positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [ISO]
- positive regulation of monooxygenase activity [ISO, ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- positive regulation of ureteric bud formation [ISO, ISS]
- postganglionic parasympathetic nervous system development [ISO, ISS]
- postsynaptic membrane organization [ISO]
- regulation of dopamine uptake involved in synaptic transmission [ISO, ISS]
- regulation of morphogenesis of a branching structure [ISO, ISS]
- regulation of ureteric bud formation [IDA]
- response to wounding [IDA]
- retina development in camera-type eye [IEP]
- sympathetic nervous system development [ISO, ISS]
- ureteric bud development [ISO]
- ureteric bud formation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Neuropilin-1 is a glial cell line-derived neurotrophic factor receptor in glioblastoma.
The aim of this study was to identify the receptor for glial cell line-derived neurotrophic factor (GDNF) in glioblastoma multiforme (GBM). After GST pull-down assays, membrane proteins purified from C6 rat glioma cells were subjected to liquid chromatography-tandem mass spectrometry (LC-MS/MS). The differentially expressed proteins were annotated using Gene Ontology, and neuropilin-1 (NRP1) was identified as the putative GDNF receptor ... [more]
Oncotarget Sep. 26, 2017; 8(43);74019-74035 [Pubmed: 29088765]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GDNF NRP1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - | |
| GDNF NRP1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID