GDNF
Gene Ontology Biological Process
- branching involved in ureteric bud morphogenesis [ISO, ISS]
- cell proliferation [IDA]
- cellular response to dexamethasone stimulus [IDA]
- enteric nervous system development [ISO, ISS]
- mRNA stabilization [ISO, ISS]
- male gonad development [IEP]
- mesenchymal to epithelial transition involved in metanephros morphogenesis [IDA]
- metanephros development [ISO, ISS]
- midbrain development [IEP]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- negative regulation of neuron apoptotic process [ISO, ISS]
- nervous system development [ISO, TAS]
- neural crest cell migration [ISO, ISS]
- neuron differentiation [IDA]
- neuron projection development [ISO, ISS]
- organ induction [ISO]
- peripheral nervous system development [ISO]
- peristalsis [ISO, ISS]
- positive regulation of branching involved in ureteric bud morphogenesis [IDA, IMP, ISO]
- positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis [ISO]
- positive regulation of monooxygenase activity [ISO, ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- positive regulation of ureteric bud formation [ISO, ISS]
- postganglionic parasympathetic nervous system development [ISO, ISS]
- postsynaptic membrane organization [ISO]
- regulation of dopamine uptake involved in synaptic transmission [ISO, ISS]
- regulation of morphogenesis of a branching structure [ISO, ISS]
- regulation of ureteric bud formation [IDA]
- response to wounding [IDA]
- retina development in camera-type eye [IEP]
- sympathetic nervous system development [ISO, ISS]
- ureteric bud development [ISO]
- ureteric bud formation [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NRP1
Gene Ontology Biological Process
- VEGF-activated neuropilin signaling pathway [ISO]
- VEGF-activated neuropilin signaling pathway involved in axon guidance [ISO]
- angiogenesis [ISO]
- angiogenesis involved in coronary vascular morphogenesis [ISO]
- artery morphogenesis [ISO]
- axon extension involved in axon guidance [ISO]
- axon guidance [IMP, ISO]
- axonal fasciculation [ISO]
- axonogenesis involved in innervation [ISO]
- cell migration [ISO]
- cell migration involved in sprouting angiogenesis [ISO]
- cellular response to hepatocyte growth factor stimulus [ISO]
- cellular response to vascular endothelial growth factor stimulus [ISO]
- commissural neuron axon guidance [ISO]
- coronary artery morphogenesis [ISO]
- dendrite development [ISO]
- dichotomous subdivision of terminal units involved in salivary gland branching [ISO]
- endothelial cell chemotaxis [ISO]
- gonadotrophin-releasing hormone neuronal migration to the hypothalamus [ISO]
- heart development [ISO]
- hepatocyte growth factor receptor signaling pathway [ISO]
- negative regulation of axon extension [ISO]
- negative regulation of axon extension involved in axon guidance [IMP, ISO]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- negative regulation of neuron apoptotic process [ISO]
- nerve development [ISO]
- nervous system development [NAS]
- neural crest cell migration involved in autonomic nervous system development [ISO]
- neuron development [ISO]
- neuron migration [ISO]
- patterning of blood vessels [ISO]
- peptidyl-tyrosine phosphorylation [ISO]
- platelet-derived growth factor receptor signaling pathway [ISO]
- positive chemotaxis [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of axon extension involved in axon guidance [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of retinal ganglion cell axon guidance [ISO]
- protein localization to early endosome [ISO]
- regulation of axon extension involved in axon guidance [ISO]
- regulation of retinal ganglion cell axon guidance [ISO]
- renal artery morphogenesis [ISO]
- response to wounding [IEP]
- retina vasculature morphogenesis in camera-type eye [ISO]
- retinal ganglion cell axon guidance [ISO]
- semaphorin-plexin signaling pathway [ISO]
- semaphorin-plexin signaling pathway involved in neuron projection guidance [ISO]
- sprouting angiogenesis [ISO]
- sympathetic ganglion development [ISO]
- sympathetic nervous system development [ISO]
- sympathetic neuron projection extension [ISO]
- sympathetic neuron projection guidance [ISO]
- toxin transport [ISO]
- trigeminal nerve morphogenesis [ISO]
- vascular endothelial growth factor receptor signaling pathway [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Neuropilin-1 is a glial cell line-derived neurotrophic factor receptor in glioblastoma.
The aim of this study was to identify the receptor for glial cell line-derived neurotrophic factor (GDNF) in glioblastoma multiforme (GBM). After GST pull-down assays, membrane proteins purified from C6 rat glioma cells were subjected to liquid chromatography-tandem mass spectrometry (LC-MS/MS). The differentially expressed proteins were annotated using Gene Ontology, and neuropilin-1 (NRP1) was identified as the putative GDNF receptor ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
GDNF NRP1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - | |
NRP1 GDNF | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID