BAIT
EGF
AI790464
epidermal growth factor
GO Process (27)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [ISO]
- STAT protein import into nucleus [IDA]
- activation of MAPKK activity [IDA]
- angiogenesis [ISO]
- branching morphogenesis of an epithelial tube [IDA]
- epidermal growth factor receptor signaling pathway [IDA, IGI, ISO]
- mammary gland alveolus development [IGI]
- negative regulation of cholesterol efflux [IDA]
- negative regulation of secretion [ISO]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of DNA binding [IDA]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of catenin import into nucleus [ISO]
- positive regulation of cell proliferation [IDA, IGI, ISO]
- positive regulation of cerebellar granule cell precursor proliferation [IDA]
- positive regulation of epidermal growth factor-activated receptor activity [ISO]
- positive regulation of hyaluronan biosynthetic process [ISO]
- positive regulation of mitosis [ISO]
- positive regulation of peptidyl-threonine phosphorylation [ISO]
- positive regulation of phosphorylation [ISO]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of calcium ion import [ISO]
- regulation of peptidyl-tyrosine phosphorylation [IDA]
- regulation of protein localization to cell surface [ISO]
- regulation of protein secretion [ISO]
- regulation of protein transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
APP
Abeta, Abpp, Adap, Ag, Cvap, E030013M08Rik, betaApp
amyloid beta (A4) precursor protein
GO Process (38)
GO Function (10)
GO Component (27)
Gene Ontology Biological Process
- adult locomotory behavior [IMP]
- axon cargo transport [IGI, IMP]
- axon midline choice point recognition [IMP]
- axonogenesis [IMP]
- cellular copper ion homeostasis [IGI, IMP]
- cholesterol metabolic process [IGI, IMP]
- collateral sprouting in absence of injury [IGI]
- dendrite development [IGI, IMP]
- endocytosis [IMP]
- extracellular matrix organization [IGI]
- forebrain development [IMP]
- ionotropic glutamate receptor signaling pathway [IMP]
- locomotory behavior [IGI]
- mRNA polyadenylation [IDA]
- mating behavior [IGI]
- negative regulation of endopeptidase activity [ISO]
- negative regulation of neuron differentiation [IDA, IGI]
- neuromuscular process controlling balance [IGI]
- neuron apoptotic process [IGI, ISO]
- neuron projection development [IDA]
- neuron remodeling [IMP]
- positive regulation of G2/M transition of mitotic cell cycle [IMP]
- positive regulation of mitotic cell cycle [IMP]
- positive regulation of peptidase activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- protein homooligomerization [ISO]
- protein phosphorylation [IMP]
- regulation of epidermal growth factor-activated receptor activity [IGI]
- regulation of gene expression [IDA]
- regulation of multicellular organism growth [IMP]
- regulation of protein binding [IGI, IMP]
- regulation of synapse structure or activity [IMP]
- regulation of translation [IDA]
- response to oxidative stress [IGI]
- smooth endoplasmic reticulum calcium ion homeostasis [IGI]
- suckling behavior [IGI]
- synaptic growth at neuromuscular junction [IGI]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- ER to Golgi transport vesicle [IDA]
- Golgi apparatus [IDA, ISO]
- apical part of cell [IDA]
- axon [IDA, ISO]
- cell [IGI]
- cell surface [ISO]
- cell-cell junction [IDA]
- ciliary rootlet [IDA]
- cytoplasm [IDA, ISO]
- cytoplasmic vesicle [IDA]
- endosome [ISO]
- extracellular space [ISO]
- extracellular vesicular exosome [ISO]
- integral component of membrane [IDA]
- intracellular [IGI]
- intracellular membrane-bounded organelle [ISO]
- membrane [IDA, TAS]
- membrane raft [ISO]
- neuromuscular junction [IDA]
- neuron projection [IDA, ISO]
- nuclear envelope lumen [ISO]
- perinuclear region of cytoplasm [IDA, ISO]
- plasma membrane [IDA, ISO]
- receptor complex [ISO]
- smooth endoplasmic reticulum [IGI]
- spindle midzone [IDA]
- terminal bouton [ISO]
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
APP Binds to the EGFR Ligands HB-EGF and EGF, Acting Synergistically with EGF to Promote ERK Signaling and Neuritogenesis.
The amyloid precursor protein (APP) is a transmembrane glycoprotein central to Alzheimer's disease (AD) with functions in brain development and plasticity, including in neurogenesis and neurite outgrowth. Epidermal growth factor (EGF) and heparin-binding EGF-like growth factor (HB-EGF) are well-described neurotrophic and neuromodulator EGFR ligands, both implicated in neurological disorders, including AD. Pro-HB-EGF arose as a putative novel APP interactor in ... [more]
Mol Neurobiol Feb. 01, 2021; 58(2);668-688 [Pubmed: 33009641]
Throughput
- Low Throughput
Curated By
- BioGRID