BAIT
CDK5R1
Cdk5r, D11Bwg0379e, p25, p35, RP23-252E4.5
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
GO Process (30)
GO Function (10)
GO Component (15)
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [ISO]
- axon guidance [IMP]
- axonal fasciculation [IMP]
- brain development [IMP]
- cerebellum development [IGI, IMP]
- cerebral cortex radially oriented cell migration [IMP]
- ephrin receptor signaling pathway [IMP]
- hippocampus development [IGI]
- ionotropic glutamate receptor signaling pathway [ISO]
- layer formation in cerebral cortex [IGI]
- negative regulation of axon extension [IGI]
- negative regulation of transcription, DNA-templated [ISO]
- neuron cell-cell adhesion [IMP]
- neuron differentiation [ISO]
- neuron migration [IDA, IGI]
- neuron projection development [ISO]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of cell cycle arrest [IMP]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of protein kinase activity [IGI]
- positive regulation of protein serine/threonine kinase activity [IMP, ISO]
- positive regulation of protein targeting to membrane [IDA]
- protein phosphorylation [ISO]
- regulation of actin cytoskeleton organization [IMP]
- regulation of cell cycle [ISO]
- regulation of dendritic spine morphogenesis [IMP]
- regulation of microtubule cytoskeleton organization [IMP]
- serine phosphorylation of STAT3 protein [IDA]
- superior olivary nucleus maturation [IGI]
Gene Ontology Molecular Function- cadherin binding [ISO]
- calcium ion binding [ISO]
- cyclin-dependent protein kinase 5 activator activity [IMP, ISO, TAS]
- cyclin-dependent protein serine/threonine kinase activity [ISO]
- cytoskeletal protein binding [TAS]
- ephrin receptor binding [ISO]
- kinase activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein serine/threonine kinase activator activity [ISO]
- cadherin binding [ISO]
- calcium ion binding [ISO]
- cyclin-dependent protein kinase 5 activator activity [IMP, ISO, TAS]
- cyclin-dependent protein serine/threonine kinase activity [ISO]
- cytoskeletal protein binding [TAS]
- ephrin receptor binding [ISO]
- kinase activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein serine/threonine kinase activator activity [ISO]
Gene Ontology Cellular Component
- axon [ISO]
- contractile fiber [ISO]
- cyclin-dependent protein kinase 5 holoenzyme complex [ISO]
- cytoplasm [IDA, ISO]
- dendrite [ISO]
- dendritic spine [ISO]
- growth cone [ISO]
- intracellular membrane-bounded organelle [ISO]
- membrane [ISO]
- neuromuscular junction [ISO]
- neuronal cell body [ISO]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [ISO]
- postsynaptic density [ISO]
Mus musculus
PREY
VLDLR
AA408956, AI451093, AW047288
very low density lipoprotein receptor
GO Process (8)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- cellular response to hypoxia [ISO]
- glycoprotein transport [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of dendrite development [IGI]
- positive regulation of protein kinase activity [IGI]
- receptor-mediated endocytosis [ISO]
- reelin-mediated signaling pathway [IGI]
- very-low-density lipoprotein particle clearance [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission.
Neuronal migration and positioning in the developing brain require the coordinated interaction of multiple cellular signaling pathways. The extracellular signaling molecule Reelin and the cytoplasmic serine/threonine kinase Cdk5 (cyclin-dependent kinase 5) are both required for normal neuronal positioning, lamination of the neocortex, and foliation of the cerebellum. They also modulate synaptic transmission in the adult brain. It is not known, ... [more]
J Neurosci Feb. 25, 2004; 24(8);1897-906 [Pubmed: 14985430]
Throughput
- Low Throughput
Curated By
- BioGRID