BAIT
RBBP8
COM1, CTIP, JWDS, RIM, SAE2, SCKL2
retinoblastoma binding protein 8
GO Process (8)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IMP]
- DNA double-strand break processing involved in repair via single-strand annealing [IMP]
- DNA repair [TAS]
- G2 DNA damage checkpoint [IDA]
- cell cycle checkpoint [TAS]
- double-strand break repair via homologous recombination [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SDCBP
MDA-9, MDA9, ST1, SYCL, TACIP18
syndecan binding protein (syntenin)
GO Process (10)
GO Function (8)
GO Component (12)
Gene Ontology Biological Process
- actin cytoskeleton organization [NAS]
- axon guidance [TAS]
- intracellular signal transduction [NAS]
- positive regulation of JNK cascade [IC]
- positive regulation of exosomal secretion [IMP]
- positive regulation of extracellular vesicular exosome assembly [IMP]
- positive regulation of phosphorylation [IDA]
- protein targeting to membrane [NAS]
- substrate-dependent cell migration, cell extension [NAS]
- synaptic transmission [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
RBBP8/CtIP suppresses P21 expression by interacting with CtBP and BRCA1 in gastric cancer.
RB Binding Protein 8 (RBBP8) was previously reported being involved in DNA double-strand break (DSB) repair in cancers. However, there is no systematic study about the specific functions and related mechanisms of RBBP8 in gastric carcinogenesis. Through immunohistochemistry staining of paired gastric cancer (GC) tissues, adjacent high-grade intraepithelial neoplasia (HGIEN) tissues, and non-cancerous tissues, we found RBBP8 expression was upregulated ... [more]
Oncogene Dec. 01, 2019; 39(6);1273-1289 [Pubmed: 31636387]
Throughput
- High Throughput
Curated By
- BioGRID