BAIT
CNR1
SKR6R
cannabinoid receptor 1 (brain)
GO Process (35)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [ISO, ISS]
- aging [IMP]
- axonal fasciculation [ISO]
- cannabinoid signaling pathway [IMP, ISO]
- glucose homeostasis [ISO]
- learning or memory [IMP]
- maternal process involved in female pregnancy [IEP]
- memory [IDA]
- negative regulation of action potential [IMP]
- negative regulation of blood pressure [IMP]
- negative regulation of dopamine secretion [IMP]
- negative regulation of fatty acid beta-oxidation [IMP]
- negative regulation of ion transport [IDA]
- negative regulation of mast cell activation [IDA]
- negative regulation of nitric-oxide synthase activity [IMP]
- positive regulation of acute inflammatory response to antigenic stimulus [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of blood pressure [IMP]
- positive regulation of fever generation [IMP]
- positive regulation of neuron projection development [IDA]
- regulation of feeding behavior [IMP]
- regulation of insulin secretion [IMP]
- regulation of lipid metabolic process [IMP]
- regulation of penile erection [IMP]
- regulation of synaptic transmission, GABAergic [IMP]
- regulation of synaptic transmission, glutamatergic [IMP]
- response to cocaine [IMP]
- response to ethanol [IMP]
- response to lipopolysaccharide [IMP]
- response to morphine [IMP]
- response to nicotine [IMP]
- response to nutrient [IEP]
- sensory perception of pain [IMP]
- spermatogenesis [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
ADORA2A
A2ar, ADENO, Adora2l1
adenosine A2a receptor
GO Process (44)
GO Function (7)
GO Component (15)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- adenosine receptor signaling pathway [IDA, ISO]
- adenylate cyclase-activating G-protein coupled receptor signaling pathway [IMP, ISO]
- astrocyte activation [IMP]
- eating behavior [IMP, ISO]
- locomotory behavior [IMP, ISO]
- membrane depolarization [IMP]
- negative regulation of alpha-beta T cell activation [ISO]
- negative regulation of cell proliferation [IDA]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of inflammatory response [ISO]
- negative regulation of locomotion [IDA]
- negative regulation of neuron apoptotic process [IDA]
- negative regulation of protein kinase activity [IDA]
- negative regulation of vascular permeability [IMP]
- neuron projection morphogenesis [IDA, IMP]
- positive regulation of acetylcholine secretion, neurotransmission [IMP]
- positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [ISO]
- positive regulation of apoptotic signaling pathway [ISO]
- positive regulation of cAMP biosynthetic process [ISO]
- positive regulation of circadian sleep/wake cycle, sleep [IDA]
- positive regulation of glutamate secretion [IDA]
- positive regulation of protein secretion [IDA]
- positive regulation of renal sodium excretion [IDA, IMP]
- positive regulation of synaptic transmission, GABAergic [ISO]
- positive regulation of synaptic transmission, glutamatergic [IDA]
- positive regulation of urine volume [IMP]
- prepulse inhibition [IMP]
- protein kinase C-activating G-protein coupled receptor signaling pathway [IDA]
- regulation of calcium ion transport [IMP]
- regulation of excitatory postsynaptic membrane potential [IDA]
- regulation of inhibitory postsynaptic membrane potential [ISO]
- regulation of mitochondrial membrane potential [IDA]
- regulation of norepinephrine secretion [IMP]
- regulation of synaptic plasticity [IDA]
- regulation of transcription, DNA-templated [IDA]
- response to alkaloid [IMP]
- response to amphetamine [ISO]
- response to caffeine [IDA]
- response to drug [IEP]
- synaptic transmission, cholinergic [IMP]
- synaptic transmission, dopaminergic [ISO]
- synaptic transmission, glutamatergic [IDA]
- vasodilation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [TAS]
- asymmetric synapse [IDA]
- axolemma [IDA]
- axon [IDA]
- dendrite [IDA]
- endomembrane system [IDA]
- integral component of plasma membrane [ISO]
- intermediate filament [IDA]
- membrane [IDA, ISO]
- neuronal cell body [IDA]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA]
- postsynaptic membrane [IDA]
- presynaptic active zone [IDA]
- presynaptic membrane [IDA]
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids.
The mechanism of action responsible for the motor depressant effects of cannabinoids, which operate through centrally expressed cannabinoid CB1 receptors, is still a matter of debate. In the present study, we report that CB1 and adenosine A2A receptors form heteromeric complexes in co-transfected HEK-293T cells and rat striatum, where they colocalize in fibrilar structures. In a human neuroblastoma cell line, ... [more]
Neuropsychopharmacology Nov. 01, 2007; 32(11);2249-59 [Pubmed: 17356572]
Throughput
- Low Throughput
Curated By
- BioGRID