BAIT
ADORA2A
A2aR, ADORA2, RDC8
adenosine A2a receptor
GO Process (15)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- activation of adenylate cyclase activity [TAS]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [TAS]
- apoptotic process [TAS]
- blood circulation [TAS]
- blood coagulation [TAS]
- cAMP biosynthetic process [TAS]
- cell-cell signaling [TAS]
- cellular defense response [TAS]
- central nervous system development [TAS]
- inflammatory response [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phagocytosis [TAS]
- positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway [IDA]
- sensory perception [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CNR1
CANN6, CB-R, CB1, CB1A, CB1K5, CB1R, CNR, RP1-23D17.1
cannabinoid receptor 1 (brain)
GO Process (3)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
FRET
An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.
Publication
Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids.
The mechanism of action responsible for the motor depressant effects of cannabinoids, which operate through centrally expressed cannabinoid CB1 receptors, is still a matter of debate. In the present study, we report that CB1 and adenosine A2A receptors form heteromeric complexes in co-transfected HEK-293T cells and rat striatum, where they colocalize in fibrilar structures. In a human neuroblastoma cell line, ... [more]
Neuropsychopharmacology Nov. 01, 2007; 32(11);2249-59 [Pubmed: 17356572]
Throughput
- Low Throughput
Additional Notes
- bioluminescence resonance energytransfer (BRET)
Curated By
- BioGRID