BAIT

CUL4A

RP11-391H12.1

cullin 4A

Fanconi Anemia Project

GO Process (4)

GO Function (1)

GO Component (2)

Gene Ontology Biological Process

G1/S transition of mitotic cell cycle [TAS]

cell cycle arrest [TAS]

intrinsic apoptotic signaling pathway [TAS]

negative regulation of cell proliferation [TAS]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

Cul4-RING E3 ubiquitin ligase complex [IDA]

Cul4A-RING E3 ubiquitin ligase complex [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

MAP2K3

MAPKK3, MEK3, MKK3, PRKMK3, SAPKK-2, SAPKK2

mitogen-activated protein kinase kinase 3

Alzheimer's Disease Project

Cell Cycle - Senescence Project

GO Process (18)

GO Function (4)

GO Component (3)

Gene Ontology Biological Process

MyD88-dependent toll-like receptor signaling pathway [TAS]

MyD88-independent toll-like receptor signaling pathway [TAS]

TRIF-dependent toll-like receptor signaling pathway [TAS]

activation of MAPK activity [TAS]

innate immune response [TAS]

positive regulation of protein kinase activity [IDA]

positive regulation of transcription, DNA-templated [IDA]

signal transduction [TAS]

stress-activated MAPK cascade [TAS]

toll-like receptor 10 signaling pathway [TAS]

toll-like receptor 2 signaling pathway [TAS]

toll-like receptor 3 signaling pathway [TAS]

toll-like receptor 4 signaling pathway [TAS]

toll-like receptor 5 signaling pathway [TAS]

toll-like receptor 9 signaling pathway [TAS]

toll-like receptor TLR1:TLR2 signaling pathway [TAS]

toll-like receptor TLR6:TLR2 signaling pathway [TAS]

toll-like receptor signaling pathway [TAS]

Gene Ontology Molecular Function

MAP kinase kinase activity [IBA]
protein binding [IPI]
protein kinase binding [IPI]
receptor signaling protein serine/threonine kinase activity [IBA]

Gene Ontology Cellular Component

nucleoplasm [TAS]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.

Minor MM, Hollinger FB, McNees AL, Jung SY, Jain A, Hyser JM, Bissig KD, Slagle BL

The hepatitis B virus (HBV) regulatory HBx protein is required for infection, and its binding to cellular damaged DNA binding protein 1 (DDB1) is critical for this function. DDB1 is an adaptor protein for the cullin 4A Really Interesting New Gene (RING) E3 ubiquitin ligase (CRL4) complex and functions by binding cellular DDB1 cullin associated factor (DCAF) receptor proteins that ... [more]

Cells Dec. 30, 2019; 9(4); [Pubmed: 32235678]

Throughput

High Throughput

Curated By

BioGRID