BAIT

CUL4A

RP11-391H12.1

cullin 4A

GO Process (4)

GO Function (1)

GO Component (2)

Gene Ontology Biological Process

G1/S transition of mitotic cell cycle [TAS]

cell cycle arrest [TAS]

intrinsic apoptotic signaling pathway [TAS]

negative regulation of cell proliferation [TAS]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

Cul4-RING E3 ubiquitin ligase complex [IDA]

Cul4A-RING E3 ubiquitin ligase complex [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

ADD1

ADDA, RP11-520M5.1

adducin 1 (alpha)

GO Process (9)

GO Function (7)

GO Component (7)

Gene Ontology Biological Process

actin cytoskeleton organization [IC]

actin filament bundle assembly [IDA]

activation of signaling protein activity involved in unfolded protein response [TAS]

apoptotic process [TAS]

barbed-end actin filament capping [IDA]

cellular component disassembly involved in execution phase of apoptosis [TAS]

cellular protein metabolic process [TAS]

endoplasmic reticulum unfolded protein response [TAS]

positive regulation of protein binding [IDA]

Gene Ontology Molecular Function

actin binding [TAS]
actin filament binding [IDA]
poly(A) RNA binding [IDA]
protein heterodimerization activity [IPI]
protein homodimerization activity [IPI]
spectrin binding [IDA]
transcription factor binding [IPI]

Gene Ontology Cellular Component

F-actin capping protein complex [IDA]

focal adhesion [IDA]

intermediate filament cytoskeleton [IDA]

nucleoplasm [IDA]

plasma membrane [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.

Minor MM, Hollinger FB, McNees AL, Jung SY, Jain A, Hyser JM, Bissig KD, Slagle BL

The hepatitis B virus (HBV) regulatory HBx protein is required for infection, and its binding to cellular damaged DNA binding protein 1 (DDB1) is critical for this function. DDB1 is an adaptor protein for the cullin 4A Really Interesting New Gene (RING) E3 ubiquitin ligase (CRL4) complex and functions by binding cellular DDB1 cullin associated factor (DCAF) receptor proteins that ... [more]

Cells Dec. 30, 2019; 9(4); [Pubmed: 32235678]

Throughput

High Throughput

Curated By

BioGRID