BAIT

CUL4A

RP11-391H12.1

cullin 4A

GO Process (4)

GO Function (1)

GO Component (2)

Gene Ontology Biological Process

G1/S transition of mitotic cell cycle [TAS]

cell cycle arrest [TAS]

intrinsic apoptotic signaling pathway [TAS]

negative regulation of cell proliferation [TAS]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

Cul4-RING E3 ubiquitin ligase complex [IDA]

Cul4A-RING E3 ubiquitin ligase complex [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

CDH2

CD325, CDHN, CDw325, NCAD

cadherin 2, type 1, N-cadherin (neuronal)

GO Process (9)

GO Function (4)

GO Component (7)

Gene Ontology Biological Process

adherens junction organization [TAS]

cell adhesion [TAS]

cell junction assembly [TAS]

cell-cell adhesion mediated by cadherin [ISS]

cell-cell junction organization [TAS]

glial cell differentiation [ISS]

muscle cell differentiation [TAS]

neuronal stem cell maintenance [ISS]

positive regulation of muscle cell differentiation [TAS]

Gene Ontology Molecular Function

alpha-catenin binding [IPI]
beta-catenin binding [TAS]
gamma-catenin binding [IPI]
protein binding [IPI]

Gene Ontology Cellular Component

catenin complex [IDA]

cell-cell adherens junction [IDA]

cell-cell junction [IDA]

extracellular vesicular exosome [IDA]

focal adhesion [IDA]

intercalated disc [ISS]

plasma membrane [TAS]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.

Minor MM, Hollinger FB, McNees AL, Jung SY, Jain A, Hyser JM, Bissig KD, Slagle BL

The hepatitis B virus (HBV) regulatory HBx protein is required for infection, and its binding to cellular damaged DNA binding protein 1 (DDB1) is critical for this function. DDB1 is an adaptor protein for the cullin 4A Really Interesting New Gene (RING) E3 ubiquitin ligase (CRL4) complex and functions by binding cellular DDB1 cullin associated factor (DCAF) receptor proteins that ... [more]

Cells Dec. 30, 2019; 9(4); [Pubmed: 32235678]

Throughput

High Throughput

Curated By

BioGRID