Co-localization

Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.

Publication

CEP44 ensures the formation of bona fide centriole wall, a requirement for the centriole-to-centrosome conversion.

Atorino ES, Hata S, Funaya C, Neuner A, Schiebel E

Centrosomes are essential organelles with functions in microtubule organization that duplicate once per cell cycle. The first step of centrosome duplication is the daughter centriole formation followed by the pericentriolar material recruitment to this centriole. This maturation step was termed centriole-to-centrosome conversion. It was proposed that CEP295-dependent recruitment of pericentriolar proteins drives centriole conversion. Here we show, based on the ... [more]

Nat Commun Dec. 14, 2019; 11(1);903 [Pubmed: 32060285]

Throughput

  • Low Throughput

Curated By

  • BioGRID