BAIT
FAM20C
DMP-4, DMP4, GEF-CK, RNS
family with sequence similarity 20, member C
GO Process (1)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PDIA6
ERP5, P5, TXNDC7
protein disulfide isomerase family A, member 6
GO Process (6)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress.
Accumulated unfolded proteins in the endoplasmic reticulum (ER) trigger the unfolded protein response (UPR) to increase ER protein folding capacity. ER proteostasis and UPR signaling need to be regulated in a precise and timely manner. Here, we identify phosphorylation of protein disulfide isomerase (PDI), one of the most abundant and critical folding catalysts in the ER, as an early event ... [more]
EMBO J Dec. 18, 2019; 39(10);e103841 [Pubmed: 32149426]
Throughput
- High Throughput
Curated By
- BioGRID