GJA1
Gene Ontology Biological Process
- atrial cardiac muscle cell action potential [TAS]
- cell communication by electrical coupling [IDA]
- cell-cell signaling [TAS]
- gap junction assembly [TAS]
- heart development [TAS]
- ion transmembrane transport [TAS]
- membrane organization [TAS]
- muscle contraction [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- signal transduction [IMP]
- transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISS]
- Golgi membrane [TAS]
- Golgi-associated vesicle membrane [TAS]
- endoplasmic reticulum membrane [TAS]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- gap junction [IDA, ISS]
- integral component of plasma membrane [TAS]
- intercalated disc [IDA, ISS]
- membrane raft [ISS]
- plasma membrane [ISS, TAS]
MAP1LC3B
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A Conserved LIR Motif in Connexins Mediates Ubiquitin-Independent Binding to LC3/GABARAP Proteins.
Gap junctions (GJ) are specialized cell-cell contacts formed by connexins (Cxs), which provide direct communication between adjacent cells. Cx43 ubiquitination has been suggested to induce the internalization of GJs, as well as the recruitment of the autophagy receptor p62 to mediate binding to LC3B and degradation by macroautophagy. In this report, we describe a functional LC3 interacting region (LIR), present ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID