NLK
Gene Ontology Biological Process
- MAPK cascade [ISS]
- intracellular signal transduction [ISS]
- negative regulation of Wnt signaling pathway [ISS]
- peptidyl-threonine phosphorylation [ISS]
- protein phosphorylation [ISS]
- regulation of transcription, DNA-templated [ISS]
- serine phosphorylation of STAT3 protein [ISS]
- transforming growth factor beta receptor signaling pathway [IMP]
Gene Ontology Molecular Function
HTT
Gene Ontology Biological Process
- Golgi organization [IMP]
- establishment of mitotic spindle orientation [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- organ development [IBA]
- positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [IDA]
- regulation of protein phosphatase type 2A activity [IMP]
- retrograde vesicle-mediated transport, Golgi to ER [IMP]
- vesicle transport along microtubule [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Nemo-like kinase reduces mutant huntingtin levels and mitigates Huntington's disease.
Nemo-like kinase (NLK), an evolutionarily conserved serine/threonine kinase, is highly expressed in the brain, but its function in the adult brain remains not well understood. In this study, we identify NLK as an interactor of huntingtin protein (HTT). We report that NLK levels are significantly decreased in HD human brain and HD models. Importantly, overexpression of NLK in the striatum ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID