BAIT
RIN3
Ras and Rab interactor 3
GO Process (2)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RAP1B
K-REV, RAL1B, OK/SW-cl.11
RAP1B, member of RAS oncogene family
GO Process (10)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- Rap protein signal transduction [IMP]
- blood coagulation [TAS]
- cellular response to cAMP [IDA]
- energy reserve metabolic process [TAS]
- establishment of endothelial barrier [IMP]
- platelet activation [TAS]
- regulation of cell junction assembly [IMP]
- regulation of establishment of cell polarity [IMP]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Upregulation of RIN3 induces endosomal dysfunction in Alzheimer's disease.
In Alzheimer's Disease (AD), about one-third of the risk genes identified by GWAS encode proteins that function predominantly in the endocytic pathways. Among them, the Ras and Rab Interactor 3(RIN3) is a guanine nucleotide exchange factor (GEF) for the Rab5 small GTPase family and has been implicated to be a risk factor for both late onset AD (LOAD) and sporadic ... [more]
Transl Neurodegener Dec. 18, 2019; 9(1);26 [Pubmed: 32552912]
Throughput
- High Throughput
Curated By
- BioGRID