TRIM24
Gene Ontology Biological Process
- calcium ion homeostasis [IMP]
- cellular response to estrogen stimulus [ISO]
- negative regulation of cell proliferation [IGI, IMP]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of gene expression [IGI, IMP]
- positive regulation of transcription, DNA-templated [IGI]
- protein autophosphorylation [IDA]
- protein catabolic process [IMP, ISO]
- protein phosphorylation [IDA]
- protein ubiquitination [IDA, ISO]
- regulation of apoptotic process [ISO]
- regulation of nucleic acid-templated transcription [ISO]
- regulation of protein stability [IMP, ISO]
- regulation of signal transduction by p53 class mediator [IGI]
- regulation of vitamin D receptor signaling pathway [IMP]
Gene Ontology Molecular Function- chromatin binding [IDA, ISO]
- estrogen response element binding [ISO]
- ligand-dependent nuclear receptor binding [IDA]
- lysine-acetylated histone binding [ISO]
- p53 binding [IPI, ISO]
- protein binding [IPI]
- protein kinase activity [IDA]
- sequence-specific DNA binding [IDA]
- transcription coactivator activity [IDA, ISO]
- ubiquitin protein ligase activity [IDA]
- ubiquitin-protein transferase activity [IDA, ISO]
- zinc ion binding [ISO]
- chromatin binding [IDA, ISO]
- estrogen response element binding [ISO]
- ligand-dependent nuclear receptor binding [IDA]
- lysine-acetylated histone binding [ISO]
- p53 binding [IPI, ISO]
- protein binding [IPI]
- protein kinase activity [IDA]
- sequence-specific DNA binding [IDA]
- transcription coactivator activity [IDA, ISO]
- ubiquitin protein ligase activity [IDA]
- ubiquitin-protein transferase activity [IDA, ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
TRAF3
Gene Ontology Biological Process
- negative regulation of NF-kappaB transcription factor activity [IMP, ISO, TAS]
- regulation of cytokine production [IMP]
- regulation of defense response to virus [IMP]
- regulation of interferon-beta production [IMP]
- regulation of proteolysis [IDA, IMP, ISO]
- toll-like receptor signaling pathway [IMP]
- tumor necrosis factor-mediated signaling pathway [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination.
Ubiquitination is an essential mechanism in the control of antiviral immunity upon virus infection. Here, we identify a series of ubiquitination-modulating enzymes that are modulated by vesicular stomatitis virus (VSV). Notably, TRIM24 is down-regulated through direct transcriptional suppression induced by VSV-activated IRF3. Reducing or ablating TRIM24 compromises type I IFN (IFN-I) induction upon RNA virus infection and thus renders mice ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID