BAIT
DNAJC11
dJ126A5.1, RP1-126A5.3
DnaJ (Hsp40) homolog, subfamily C, member 11
GO Process (0)
GO Function (1)
GO Component (1)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PNP
NP, PRO1837, PUNP
purine nucleoside phosphorylase
GO Process (15)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- NAD biosynthesis via nicotinamide riboside salvage pathway [IGI]
- immune response [IMP]
- inosine catabolic process [IDA]
- interleukin-2 secretion [IMP]
- nicotinamide riboside catabolic process [IDA]
- nucleobase-containing compound metabolic process [IDA]
- nucleobase-containing small molecule metabolic process [TAS]
- positive regulation of T cell proliferation [IDA]
- positive regulation of alpha-beta T cell differentiation [IDA]
- purine nucleobase metabolic process [TAS]
- purine nucleotide catabolic process [TAS]
- purine-containing compound salvage [TAS]
- response to drug [IDA, IMP]
- small molecule metabolic process [TAS]
- urate biosynthetic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.
Hsp70s comprise a deeply conserved chaperone family that has a central role in maintaining protein homeostasis. In humans, Hsp70 client specificity is provided by 49 different co-factors known as J domain proteins (JDPs). However, the cellular function and client specificity of JDPs have largely remained elusive. We have combined affinity purification-mass spectrometry (AP-MS) and proximity-dependent biotinylation (BioID) to characterize the ... [more]
Mol Cell Apr. 27, 2021; (); [Pubmed: 33957083]
Quantitative Score
- 4.59 [FoldChange]
Throughput
- High Throughput
Additional Notes
- High confidence interactions were identified as having an average probability of the identified interaction (AvgP) >= 0.98. The associated score represents the fold change of spectral counts (or intensities) for each individual interaction.
Curated By
- BioGRID