BAIT
TOPORS
LUN, P53BP3, RP31, TP53BPL, RP11-205M20.5
topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
GO Process (16)
GO Function (6)
GO Component (11)
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IDA]
- intrinsic apoptotic signaling pathway in response to DNA damage [IDA]
- maintenance of protein location in nucleus [IDA]
- negative regulation of apoptotic process [ISS]
- photoreceptor cell outer segment organization [ISS]
- positive regulation of ubiquitin-protein transferase activity [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein K48-linked ubiquitination [IDA]
- protein localization to nucleus [IMP]
- protein monoubiquitination [IDA]
- protein sumoylation [IDA, IMP]
- retina layer formation [ISS]
- retinal cone cell development [ISS]
- retinal rod cell development [ISS]
- transcription, DNA-templated [NAS]
- ubiquitin-dependent protein catabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
UBE2I
C358B7.1, P18, UBC9, LA16c-358B7.1
ubiquitin-conjugating enzyme E2I
GO Process (8)
GO Function (9)
GO Component (6)
Gene Ontology Biological Process
- cellular protein metabolic process [TAS]
- cellular protein modification process [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IDA]
- post-translational protein modification [TAS]
- protein sumoylation [IDA, TAS]
- protein ubiquitination [IBA]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The DNA topoisomerase I binding protein topors as a novel cellular target for SUMO-1 modification: characterization of domains necessary for subcellular localization and sumolation.
Over the past years, modification by covalent attachment of SUMO (small ubiquitin-like modifier) has been demonstrated for of a number of cellular and viral proteins. While increasing evidence suggests a role for SUMO modification in the regulation of protein-protein interactions and/or subcellular localization, most SUMO targets are still at large. In this report we show that Topors, a Topoisomerase I ... [more]
Exp. Cell Res. Oct. 15, 2003; 290(1);13-27 [Pubmed: 14516784]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TOPORS UBE2I | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID