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BAIT

CTTN

EMS1

cortactin

GO Process (9)

GO Function (1)

GO Component (12)

Gene Ontology Biological Process

actin cytoskeleton reorganization [ISS]

cell motility [ISS]

focal adhesion assembly [ISS]

intracellular protein transport [IMP]

lamellipodium organization [ISS]

neuron projection morphogenesis [ISS]

positive regulation of actin filament polymerization [ISS]

receptor-mediated endocytosis [ISS]

regulation of axon extension [ISS]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

actin filament [IDA]

cell cortex [ISS]

coated pit [ISS]

cortical cytoskeleton [IDA]

cytoplasm [IDA, ISS]

cytoskeleton [TAS]

extracellular vesicular exosome [IDA]

focal adhesion [IDA]

growth cone [ISS]

lamellipodium [IDA, ISS]

voltage-gated potassium channel complex [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

LRPAP1

A2MRAP, A2RAP, HBP44, MRAP, MYP23, RAP, alpha-2-MRAP, RP11-529E10.3

low density lipoprotein receptor-related protein associated protein 1

Alzheimer's Disease Project

GO Process (7)

GO Function (6)

GO Component (4)

Gene Ontology Biological Process

extracellular negative regulation of signal transduction [IDA]

negative regulation of beta-amyloid clearance [IGI]

negative regulation of protein binding [IDA]

negative regulation of very-low-density lipoprotein particle clearance [IDA]

protein folding [TAS]

receptor-mediated endocytosis [TAS]

vesicle-mediated transport [TAS]

Gene Ontology Molecular Function

asialoglycoprotein receptor activity [TAS]
low-density lipoprotein particle receptor binding [IDA]
protein binding [IPI]
receptor antagonist activity [IDA]
unfolded protein binding [TAS]
very-low-density lipoprotein particle receptor binding [IPI]

Gene Ontology Cellular Component

endoplasmic reticulum [IDA]

extracellular region [IDA]

integral component of membrane [TAS]

plasma membrane [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.

Marcon E, Ni Z, Pu S, Turinsky AL, Trimble SS, Olsen JB, Silverman-Gavrila R, Silverman-Gavrila L, Phanse S, Guo H, Zhong G, Guo X, Young P, Bailey S, Roudeva D, Zhao D, Hewel J, Li J, Graeslund S, Paduch M, Kossiakoff AA, Lupien M, Emili A, Wodak SJ, Greenblatt J

Chromatin regulation is driven by multicomponent protein complexes, which form functional modules. Deciphering the components of these modules and their interactions is central to understanding the molecular pathways these proteins are regulating, their functions, and their relation to both normal development and disease. We describe the use of affinity purifications of tagged human proteins coupled with mass spectrometry to generate ... [more]

Cell Rep Jul. 10, 2014; 8(1);297-310 [Pubmed: 24981860]

Quantitative Score

23.80126302 [HGSCore]

Throughput

High Throughput

Additional Notes

Affinity Capture MS carried out to identify high confidence protein interactions with a iHGSCore < 11

Curated By

BioGRID