BAIT
KDM2B
CXXC2, FBXL10, Fbl10, JHDM1B, PCCX2
lysine (K)-specific demethylase 2B
GO Process (15)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- embryonic camera-type eye morphogenesis [ISS]
- forebrain development [ISS]
- fourth ventricle development [ISS]
- hindbrain development [ISS]
- histone H2A monoubiquitination [IDA]
- histone demethylation [TAS]
- initiation of neural tube closure [ISS]
- lateral ventricle development [ISS]
- midbrain development [ISS]
- midbrain-hindbrain boundary morphogenesis [ISS]
- negative regulation of neural precursor cell proliferation [ISS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- spermatogenesis [ISS]
- third ventricle development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CSNK2A2
CK2A2, CSNK2A1
casein kinase 2, alpha prime polypeptide
GO Process (3)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.
Chromatin regulation is driven by multicomponent protein complexes, which form functional modules. Deciphering the components of these modules and their interactions is central to understanding the molecular pathways these proteins are regulating, their functions, and their relation to both normal development and disease. We describe the use of affinity purifications of tagged human proteins coupled with mass spectrometry to generate ... [more]
Cell Rep Jul. 10, 2014; 8(1);297-310 [Pubmed: 24981860]
Quantitative Score
- 19.5108575 [HGSCore]
Throughput
- High Throughput
Additional Notes
- Affinity Capture MS carried out to identify high confidence protein interactions with a iHGSCore < 11
Curated By
- BioGRID