BAIT
C3
AHUS5, ARMD9, ASP, C3a, C3b, CPAMD1, HEL-S-62p
complement component 3
GO Process (15)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- complement activation [IMP, TAS]
- complement activation, alternative pathway [TAS]
- immune response [TAS]
- innate immune response [TAS]
- positive regulation of G-protein coupled receptor protein signaling pathway [IDA]
- positive regulation of apoptotic cell clearance [IMP]
- positive regulation of glucose transport [IDA]
- positive regulation of lipid storage [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation vascular endothelial growth factor production [IDA]
- regulation of complement activation [TAS]
- regulation of immune response [TAS]
- regulation of triglyceride biosynthetic process [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HRG
HPRG, HRGP, THPH11
histidine-rich glycoprotein
GO Process (24)
GO Function (8)
GO Component (5)
Gene Ontology Biological Process
- blood coagulation [TAS]
- defense response to fungus [IDA]
- fibrinolysis [TAS]
- negative regulation of angiogenesis [IDA]
- negative regulation of blood vessel endothelial cell migration [ISS]
- negative regulation of cell adhesion [IDA]
- negative regulation of cell adhesion mediated by integrin [IDA]
- negative regulation of cell growth [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of endothelial cell chemotaxis [IDA]
- negative regulation of lamellipodium assembly [IDA]
- negative regulation of vascular endothelial growth factor signaling pathway [IDA]
- platelet activation [IDA, TAS]
- platelet degranulation [TAS]
- positive regulation of apoptotic process [IDA]
- positive regulation of blood vessel remodeling [IDA]
- positive regulation of focal adhesion assembly [IDA]
- positive regulation of immune response to tumor cell [IDA]
- regulation of actin cytoskeleton organization [IDA]
- regulation of blood coagulation [IDA]
- regulation of gene expression [IDA]
- regulation of peptidyl-tyrosine phosphorylation [IDA]
- regulation of platelet activation [ISS]
- regulation of protein complex assembly [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.
Chromatin regulation is driven by multicomponent protein complexes, which form functional modules. Deciphering the components of these modules and their interactions is central to understanding the molecular pathways these proteins are regulating, their functions, and their relation to both normal development and disease. We describe the use of affinity purifications of tagged human proteins coupled with mass spectrometry to generate ... [more]
Cell Rep Jul. 10, 2014; 8(1);297-310 [Pubmed: 24981860]
Quantitative Score
- 14.89003841 [HGSCore]
Throughput
- High Throughput
Additional Notes
- Affinity Capture MS carried out to identify high confidence protein interactions with a iHGSCore < 11
Curated By
- BioGRID