BAIT
C14ORF169
MAPJD, NO66, ROX, hsNO66
chromosome 14 open reading frame 169
GO Process (4)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function- histone demethylase activity (H3-K36 specific) [ISS]
- histone demethylase activity (H3-K4 specific) [ISS]
- iron ion binding [ISS]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [ISS]
- protein binding [IPI]
- histone demethylase activity (H3-K36 specific) [ISS]
- histone demethylase activity (H3-K4 specific) [ISS]
- iron ion binding [ISS]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [ISS]
- protein binding [IPI]
Homo sapiens
PREY
NDUFS7
CI-20, CI-20KD, MY017, PSST
NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
GO Process (5)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.
Chromatin regulation is driven by multicomponent protein complexes, which form functional modules. Deciphering the components of these modules and their interactions is central to understanding the molecular pathways these proteins are regulating, their functions, and their relation to both normal development and disease. We describe the use of affinity purifications of tagged human proteins coupled with mass spectrometry to generate ... [more]
Cell Rep Jul. 10, 2014; 8(1);297-310 [Pubmed: 24981860]
Quantitative Score
- 14.4692212 [HGSCore]
Throughput
- High Throughput
Additional Notes
- Affinity Capture MS carried out to identify high confidence protein interactions with a iHGSCore < 11
Curated By
- BioGRID