BAIT
CTR9
SH2BP1, TSBP, p150, p150TSP
CTR9, Paf1/RNA polymerase II complex component
GO Process (14)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- JAK-STAT cascade [ISS]
- cellular response to lipopolysaccharide [ISS]
- endodermal cell fate commitment [ISS]
- histone H2B ubiquitination [IDA]
- histone H3-K4 trimethylation [IMP]
- histone monoubiquitination [IDA]
- interleukin-6-mediated signaling pathway [ISS]
- negative regulation of myeloid cell differentiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of histone H3-K4 methylation [IMP]
- positive regulation of histone H3-K79 methylation [IMP]
- positive regulation of transcription elongation from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- stem cell maintenance [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ACACA
ACAC, ACACAD, ACC, ACC1, ACCA
acetyl-CoA carboxylase alpha
GO Process (13)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
- acetyl-CoA metabolic process [ISS]
- biotin metabolic process [TAS]
- carnitine shuttle [TAS]
- cellular lipid metabolic process [TAS]
- energy reserve metabolic process [TAS]
- fatty acid biosynthetic process [ISS]
- long-chain fatty-acyl-CoA biosynthetic process [TAS]
- positive regulation of cellular metabolic process [TAS]
- protein homotetramerization [ISS]
- small molecule metabolic process [TAS]
- triglyceride biosynthetic process [TAS]
- vitamin metabolic process [TAS]
- water-soluble vitamin metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.
Chromatin regulation is driven by multicomponent protein complexes, which form functional modules. Deciphering the components of these modules and their interactions is central to understanding the molecular pathways these proteins are regulating, their functions, and their relation to both normal development and disease. We describe the use of affinity purifications of tagged human proteins coupled with mass spectrometry to generate ... [more]
Cell Rep Jul. 10, 2014; 8(1);297-310 [Pubmed: 24981860]
Quantitative Score
- 13.9326036 [HGSCore]
Throughput
- High Throughput
Additional Notes
- Affinity Capture MS carried out to identify high confidence protein interactions with a iHGSCore < 11
Curated By
- BioGRID