BAIT
NDUFA4
CI-9k, CI-MLRQ, MLRQ
NDUFA4, mitochondrial complex associated
GO Process (5)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PARP16
ARTD15, C15orf30, pART15
poly (ADP-ribose) polymerase family, member 16
GO Process (6)
GO Function (4)
GO Component (4)
Gene Ontology Biological Process
- activation of signaling protein activity involved in unfolded protein response [IMP]
- endoplasmic reticulum unfolded protein response [IMP]
- negative regulation of cell death [IMP]
- positive regulation of protein serine/threonine kinase activity [IMP]
- protein ADP-ribosylation [IMP]
- protein auto-ADP-ribosylation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.
Chromatin regulation is driven by multicomponent protein complexes, which form functional modules. Deciphering the components of these modules and their interactions is central to understanding the molecular pathways these proteins are regulating, their functions, and their relation to both normal development and disease. We describe the use of affinity purifications of tagged human proteins coupled with mass spectrometry to generate ... [more]
Cell Rep Jul. 10, 2014; 8(1);297-310 [Pubmed: 24981860]
Quantitative Score
- 12.53008535 [HGSCore]
Throughput
- High Throughput
Additional Notes
- Affinity Capture MS carried out to identify high confidence protein interactions with a iHGSCore < 11
Curated By
- BioGRID