POU2F1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
STAT3
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [IDA, ISS, TAS]
- astrocyte differentiation [ISS]
- cellular component movement [TAS]
- cellular response to hormone stimulus [IDA]
- cytokine-mediated signaling pathway [NAS]
- eating behavior [ISS]
- eye photoreceptor cell differentiation [ISS]
- glucose homeostasis [ISS]
- growth hormone receptor signaling pathway [IDA]
- interleukin-6-mediated signaling pathway [IDA]
- intracellular receptor signaling pathway [IDA]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- nervous system development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphorylation [ISS]
- positive regulation of Notch signaling pathway [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [ISS]
- protein import into nucleus [IDA]
- radial glial cell differentiation [ISS]
- regulation of transcription from RNA polymerase II promoter [ISS]
- regulation of transcription, DNA-templated [IDA]
- response to estradiol [IDA]
- sexual reproduction [ISS]
- signal transduction [TAS]
- temperature homeostasis [ISS]
Gene Ontology Molecular Function- DNA binding [ISS]
- RNA polymerase II repressing transcription factor binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein dimerization activity [ISS]
- protein kinase binding [ISS]
- protein phosphatase binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- DNA binding [ISS]
- RNA polymerase II repressing transcription factor binding [IPI]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- protein dimerization activity [ISS]
- protein kinase binding [ISS]
- protein phosphatase binding [IPI]
- sequence-specific DNA binding transcription factor activity [TAS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal.
Cancer stem cells (CSCs) have key roles in treatment resistance, tumour metastasis and relapse. Using colorectal cancer (CC) cell lines, patient-derived xenograft (PDX) tissues and patient tissues, here we report that CC CSCs, which resist chemoradiation, have higher SUMO activating enzyme (E1) and global SUMOylation levels than non-CSCs. Knockdown of SUMO E1 or SUMO conjugating enzyme (E2) inhibits CC CSC ... [more]
Quantitative Score
- 2.06 [Custom Score]
Throughput
- High Throughput
Additional Notes
- Oct1 was affinity purified and associated proteins were identified by mass spectrometry. The method of scoring used was not indicated, but scoring was presumably performed by the Proteome Discoverer 1.4 software. Higher scores presumably indicate higher confidence in the interaction.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| POU2F1 STAT3 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | - | BioGRID | 3438402 |
Curated By
- BioGRID