PHRF1
Gene Ontology Molecular Function
CSNK2B
Gene Ontology Biological Process
- adiponectin-activated signaling pathway [IDA]
- axon guidance [TAS]
- cellular protein complex assembly [NAS]
- endothelial tube morphogenesis [IMP]
- mitotic cell cycle [TAS]
- negative regulation of blood vessel endothelial cell migration [IDA]
- negative regulation of cell proliferation [TAS]
- positive regulation of activin receptor signaling pathway [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- protein phosphorylation [TAS]
- regulation of DNA binding [NAS]
- regulation of protein kinase activity [NAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.
The mammalian mRNA nuclear export process is thought to terminate at the cytoplasmic face of the nuclear pore complex through ribonucleoprotein remodeling. We conduct a stringent affinity-purification mass-spectrometry-based screen of the physical interactions of human RNA-binding E3 ubiquitin ligases. The resulting protein-interaction network reveals interactions between the RNA-binding E3 ubiquitin ligase MKRN2 and GLE1, a DEAD-box helicase activator implicated in ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CSNK2B PHRF1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 1 | BioGRID | 3142063 | |
| CSNK2B PHRF1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID