BAIT
MKRN2
RNF62, HSPC070
makorin ring finger protein 2
GO Process (0)
GO Function (2)
GO Component (1)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RIMS2
OBOE, RAB3IP3, RIM2
regulating synaptic membrane exocytosis 2
GO Process (9)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- cAMP-mediated signaling [ISS]
- calcium ion-dependent exocytosis [ISS]
- calcium ion-dependent exocytosis of neurotransmitter [ISS]
- insulin secretion [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of gene expression [ISS]
- positive regulation of inhibitory postsynaptic membrane potential [ISS]
- regulation of exocytosis [ISS]
- regulation of membrane potential [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.
The mammalian mRNA nuclear export process is thought to terminate at the cytoplasmic face of the nuclear pore complex through ribonucleoprotein remodeling. We conduct a stringent affinity-purification mass-spectrometry-based screen of the physical interactions of human RNA-binding E3 ubiquitin ligases. The resulting protein-interaction network reveals interactions between the RNA-binding E3 ubiquitin ligase MKRN2 and GLE1, a DEAD-box helicase activator implicated in ... [more]
Cell Rep Dec. 26, 2019; 31(8);107693 [Pubmed: 32460013]
Throughput
- High Throughput
Curated By
- BioGRID