BAIT
MKRN2
RNF62, HSPC070
makorin ring finger protein 2
GO Process (0)
GO Function (2)
GO Component (1)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SEMA4D
C9orf164, CD100, M-sema-G, SEMAJ, coll-4, XXyac-YM68G7.1
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
GO Process (22)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- axon guidance [TAS]
- cell adhesion [TAS]
- immune response [TAS]
- leukocyte aggregation [IMP]
- negative regulation of alkaline phosphatase activity [IMP]
- negative regulation of apoptotic process [TAS]
- negative regulation of cell adhesion [IDA]
- negative regulation of osteoblast differentiation [ISS]
- negative regulation of peptidyl-tyrosine phosphorylation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- ossification involved in bone maturation [IMP]
- positive regulation of Rho GTPase activity [IMP, ISS]
- positive regulation of cell migration [IDA, ISS]
- positive regulation of collateral sprouting [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [ISS]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of protein phosphorylation [IDA]
- regulation of cell projection organization [IMP]
- regulation of cell shape [IMP]
- regulation of dendrite morphogenesis [IMP]
- semaphorin-plexin signaling pathway [IDA, IMP]
- semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.
The mammalian mRNA nuclear export process is thought to terminate at the cytoplasmic face of the nuclear pore complex through ribonucleoprotein remodeling. We conduct a stringent affinity-purification mass-spectrometry-based screen of the physical interactions of human RNA-binding E3 ubiquitin ligases. The resulting protein-interaction network reveals interactions between the RNA-binding E3 ubiquitin ligase MKRN2 and GLE1, a DEAD-box helicase activator implicated in ... [more]
Cell Rep Dec. 26, 2019; 31(8);107693 [Pubmed: 32460013]
Throughput
- High Throughput
Curated By
- BioGRID