BAIT
MKRN2
RNF62, HSPC070
makorin ring finger protein 2
GO Process (0)
GO Function (2)
GO Component (1)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
WNT5A
hWNT5A
wingless-type MMTV integration site family, member 5A
GO Process (54)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- Wnt signaling pathway [IDA]
- Wnt signaling pathway, calcium modulating pathway [IDA, IMP]
- activation of JUN kinase activity [IDA, IMP]
- activation of MAPK activity [IDA]
- activation of protein kinase B activity [IDA]
- axon guidance [ISS]
- cell fate commitment [IBA]
- cellular protein localization [IDA]
- cellular response to calcium ion [IEP]
- cellular response to interferon-gamma [IEP]
- cellular response to lipopolysaccharide [IEP]
- cellular response to retinoic acid [ISS]
- cellular response to transforming growth factor beta stimulus [IEP]
- embryonic skeletal system development [IMP]
- epithelial to mesenchymal transition [IEP]
- face development [IMP]
- genitalia development [IMP]
- hematopoietic stem cell proliferation [IDA]
- keratinocyte differentiation [IEP]
- lens development in camera-type eye [ISS]
- male gonad development [IEP]
- negative regulation of apoptotic process [IDA]
- negative regulation of canonical Wnt signaling pathway [IDA, IGI]
- negative regulation of fat cell differentiation [IMP]
- negative regulation of mesenchymal cell proliferation [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neuron differentiation [IBA, ISS]
- olfactory bulb interneuron development [ISS]
- optic cup formation involved in camera-type eye development [ISS]
- palate development [IMP]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of T cell chemotaxis [IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of cGMP metabolic process [IDA]
- positive regulation of chemokine biosynthetic process [IMP]
- positive regulation of cytokine secretion involved in immune response [IMP]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of inflammatory response [IMP]
- positive regulation of interleukin-1 beta secretion [IMP]
- positive regulation of interleukin-6 production [IMP]
- positive regulation of macrophage activation [IMP]
- positive regulation of macrophage cytokine production [IMP]
- positive regulation of neuron projection development [ISS]
- positive regulation of ossification [IMP]
- positive regulation of protein catabolic process [IGI]
- positive regulation of protein kinase C signaling [IMP]
- positive regulation of response to cytokine stimulus [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of type I interferon-mediated signaling pathway [IDA]
- response to organic substance [IEP]
- wound healing [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.
The mammalian mRNA nuclear export process is thought to terminate at the cytoplasmic face of the nuclear pore complex through ribonucleoprotein remodeling. We conduct a stringent affinity-purification mass-spectrometry-based screen of the physical interactions of human RNA-binding E3 ubiquitin ligases. The resulting protein-interaction network reveals interactions between the RNA-binding E3 ubiquitin ligase MKRN2 and GLE1, a DEAD-box helicase activator implicated in ... [more]
Cell Rep Dec. 26, 2019; 31(8);107693 [Pubmed: 32460013]
Throughput
- High Throughput
Curated By
- BioGRID