An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Ubiquitin C-terminal hydrolase L1 (UCHL1) regulates post-myocardial infarction cardiac fibrosis through glucose-regulated protein of 78 kDa (GRP78).

Lei Q, Yi T, Li H, Yan Z, Lv Z, Li G, Wang Y

Abnormal cardiac fibrosis indicates cardiac dysfunction and poor prognosis in myocardial infarction (MI) patients. Many studies have demonstrated that the ubiquitin proteasome system (UPS) plays a significant role in the pathogenesis of fibrosis. Ubiquitin C-terminal hydrolase L1 (UCHL1), a member of the UPS, is related to fibrosis in several heart diseases. However, whether UCHL1 regulates cardiac fibrosis following MI has ... [more]

Sci Rep Dec. 30, 2019; 10(1);10604 [Pubmed: 32606430]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

UCHL1

Gene Ontology Biological Process

Gene Ontology Molecular Function

alpha-2A adrenergic receptor binding [IPI]cysteine-type endopeptidase activity [IDA]omega peptidase activity [IDA]protein binding [IPI]ubiquitin binding [IDA]ubiquitin thiolesterase activity [TAS]

Gene Ontology Cellular Component

PYGB