USP19
Gene Ontology Biological Process
- ER-associated ubiquitin-dependent protein catabolic process [IDA]
- negative regulation of skeletal muscle tissue development [ISS]
- positive regulation of cell cycle process [ISS]
- protein deubiquitination [IBA, ISS]
- regulation of cellular response to hypoxia [IMP]
- regulation of proteasomal protein catabolic process [IBA]
- regulation of protein stability [ISS]
- response to endoplasmic reticulum stress [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PIK3C3
Gene Ontology Biological Process
- cytokinesis [IMP]
- early endosome to late endosome transport [IMP]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol-3-phosphate biosynthetic process [IMP, TAS]
- phospholipid metabolic process [TAS]
- small molecule metabolic process [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
High-throughput screening of functional deubiquitinating enzymes in autophagy.
Macroautophagy/autophagy, a eukaryotic homeostatic process that sequesters cytoplasmic constituents for lysosomal degradation, is orchestrated by a number of autophagy-related (ATG) proteins tightly controlled by post-translational modifications. However, the involvement of reversible ubiquitination in the regulation of autophagy remains largely unclear. Here, we performed a single-guide RNA-based screening assay to investigate the functions of deubiquitinating enzymes (DUBs) in regulating autophagy. We ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID