FZR1
Gene Ontology Biological Process
- G2 DNA damage checkpoint [ISO]
- activation of anaphase-promoting complex activity [ISO]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [ISO]
- lens fiber cell differentiation [IMP]
- negative regulation of cell aging [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of protein catabolic process [ISO]
- regulation of meiosis [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FXR1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.
Maintaining a balance between protein degradation and protein synthesis is necessary for neurodevelopment. Although the E3 ubiquitin ligase anaphase promoting complex and its regulatory subunit Cdh1 (Cdh1-APC) has been shown to regulate learning and memory, the underlying mechanisms are unclear. Here, we have identified a role of Cdh1-APC as a regulator of protein synthesis in neurons. Proteomic profiling revealed that ... [more]
Quantitative Score
- 13.0 [Custom Score]
Throughput
- High Throughput
Additional Notes
- FLAG-tagged Cdh1 was affinity purified and associated proteins were identified by mass spectrometry. Scoring type was unclear, but higher values indicate higher confidence in the interaction. High confidence scores for FLAG-CDH1-transfected cells with no competing peptide (13) are reported here. Negative control scores were those for non-transfected cells (0), non-transfected cells with competing FLAG peptide (0) and FLAG-CDH1-transfected cells with competing FLAG peptide (0).
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FZR1 FXR1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID