BAIT
RNF128
GRAIL, RP11-150F24.1
ring finger protein 128, E3 ubiquitin protein ligase
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens
PREY
ATP6V0A1
ATP6N1, ATP6N1A, Stv1, VPP1, Vph1, a1
ATPase, H+ transporting, lysosomal V0 subunit a1
GO Process (9)
GO Function (3)
GO Component (9)
Gene Ontology Biological Process
- ATP synthesis coupled proton transport [IBA]
- cellular iron ion homeostasis [TAS]
- insulin receptor signaling pathway [TAS]
- interaction with host [TAS]
- phagosome maturation [TAS]
- transferrin transport [TAS]
- transmembrane transport [TAS]
- vacuolar acidification [IBA]
- vacuolar proton-transporting V-type ATPase complex assembly [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling.
Ubiquitin ligases (E3s) embedded in the endoplasmic reticulum (ER) membrane regulate essential cellular activities including protein quality control, calcium flux, and sterol homeostasis. At least 25 different, transmembrane domain (TMD)-containing E3s are predicted to be ER-localised, but for most their organisation and cellular roles remain poorly defined. Using a comparative proteomic workflow, we mapped over 450 protein-protein interactions for 21 ... [more]
Elife Dec. 02, 2019; 9(); [Pubmed: 32614325]
Throughput
- High Throughput
Curated By
- BioGRID