BAIT
RNF139
HRCA1, RCA1, TRC8
ring finger protein 139
GO Process (8)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- negative regulation of cell proliferation [IDA]
- negative regulation of translation [IDA]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- protein destabilization [IMP]
- protein ubiquitination [IDA, IMP]
- regulation of ER to Golgi vesicle-mediated transport [IDA]
- regulation of protein processing [IDA]
- regulation of protein ubiquitination [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
AFG3L2
SCA28, SPAX5
AFG3-like AAA ATPase 2
GO Process (0)
GO Function (2)
GO Component (1)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling.
Ubiquitin ligases (E3s) embedded in the endoplasmic reticulum (ER) membrane regulate essential cellular activities including protein quality control, calcium flux, and sterol homeostasis. At least 25 different, transmembrane domain (TMD)-containing E3s are predicted to be ER-localised, but for most their organisation and cellular roles remain poorly defined. Using a comparative proteomic workflow, we mapped over 450 protein-protein interactions for 21 ... [more]
Elife Dec. 02, 2019; 9(); [Pubmed: 32614325]
Throughput
- High Throughput
Curated By
- BioGRID