FBXO2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
IL6R
Gene Ontology Biological Process
- acute-phase response [TAS]
- ciliary neurotrophic factor-mediated signaling pathway [IMP]
- cytokine-mediated signaling pathway [IDA]
- defense response to Gram-negative bacterium [IEP]
- defense response to Gram-positive bacterium [IEP]
- endocrine pancreas development [IC, IMP]
- extrinsic apoptotic signaling pathway [TAS]
- hepatic immune response [TAS]
- interleukin-6-mediated signaling pathway [IMP]
- monocyte chemotaxis [IC]
- negative regulation of collagen biosynthetic process [IDA]
- negative regulation of interleukin-8 production [IEP]
- neutrophil mediated immunity [IC]
- positive regulation of MAPK cascade [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of activation of Janus kinase activity [IDA]
- positive regulation of cell proliferation [IDA, IMP]
- positive regulation of chemokine production [IDA]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of leukocyte chemotaxis [IC, TAS]
- positive regulation of osteoblast differentiation [TAS]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IMP]
- response to cytokine [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
FBXO2 modulates STAT3 signaling to regulate proliferation and tumorigenicity of osteosarcoma cells.
Osteosarcoma (OS) is the most common primary bone malignancy in children and adolescents, and hyperproliferation of cells is a major problem of OS. FBXO2 belongs to the family of F-box proteins, and is a substrate recognition component of the Skp1-Cul1-F-box protein (SCF) E3 ubiquitin ligase complex with specificity for high-mannose glycoproteins. The aim of the present study was to investigate ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID