BAIT
DDX58
RIG-I, RIGI, RLR-1, RP11-334P12.2
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
GO Process (14)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- RIG-I signaling pathway [IMP]
- cytoplasmic pattern recognition receptor signaling pathway in response to virus [TAS]
- detection of virus [IDA]
- innate immune response [IMP, TAS]
- negative regulation of type I interferon production [TAS]
- positive regulation of defense response to virus by host [IMP]
- positive regulation of interferon-alpha production [IDA, IMP]
- positive regulation of interferon-beta production [IDA, IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IC]
- positive regulation of transcription factor import into nucleus [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of cell migration [IDA]
- regulation of type III interferon production [TAS]
- response to virus [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ADRA1A
ADRA1C, ADRA1L1, ALPHA1AAR
adrenoceptor alpha 1A
GO Process (22)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- activation of phospholipase C activity [ISS]
- adrenergic receptor signaling pathway [ISS, NAS, TAS]
- aging [ISS]
- apoptotic process [TAS]
- calcium ion transport into cytosol [ISS]
- cell-cell signaling [TAS]
- intracellular signal transduction [TAS]
- negative regulation of Rho protein signal transduction [ISS]
- negative regulation of cell proliferation [TAS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of MAPK cascade [IDA]
- positive regulation of action potential [ISS]
- positive regulation of cardiac muscle contraction [ISS]
- positive regulation of cytosolic calcium ion concentration [ISS]
- positive regulation of protein kinase C signaling [ISS]
- positive regulation of synaptic transmission, GABAergic [ISS]
- positive regulation of vasoconstriction [ISS]
- response to drug [ISS]
- response to hormone [ISS]
- signal transduction [TAS]
- smooth muscle contraction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation.
Retinoic acid-inducible gene I (RIG-I) is up-regulated during granulocytic differentiation of acute promyelocytic leukemia (APL) cells induced by all-trans retinoic acid (ATRA). It has been reported that RIG-I recognizes virus-specific 5'-ppp-double-stranded RNA (dsRNA) and activates the type I interferons signaling pathways in innate immunity. However, the functions of RIG-I in hematopoiesis remain unclear, especially regarding its possible interaction with endogenous ... [more]
Proc Natl Acad Sci U S A Dec. 23, 2019; 117(25);14395-14404 [Pubmed: 32513696]
Throughput
- High Throughput
Curated By
- BioGRID