BAIT
UBE3A
ANCR, AS, E6-AP, EPVE6AP, HPVE6A
ubiquitin protein ligase E3A
GO Process (9)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- androgen receptor signaling pathway [IBA]
- brain development [TAS]
- protein K48-linked ubiquitination [IDA]
- protein autoubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA]
- proteolysis [TAS]
- regulation of circadian rhythm [IMP]
- regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
CRP
PTX1, RP11-419N10.4
C-reactive protein, pentraxin-related
GO Process (10)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
- acute-phase response [TAS]
- defense response to Gram-positive bacterium [TAS]
- inflammatory response [TAS]
- negative regulation of lipid storage [IDA]
- negative regulation of macrophage derived foam cell differentiation [IDA]
- negative regulation of vasodilation [IDA, IMP]
- opsonization [TAS]
- positive regulation of gene expression [IDA]
- positive regulation of superoxide anion generation [IDA]
- regulation of interleukin-8 secretion [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
An Integrative Synthetic Biology Approach to Interrogating Cellular Ubiquitin and Ufm Signaling.
Global identification of substrates for PTMs (post-translational modifications) represents a critical but yet dauntingly challenging task in understanding biology and disease pathology. Here we presented a synthetic biology approach, namely 'YESS', which coupled Y2H (yeast two hybrid) interactome screening with PTMs reactions reconstituted in bacteria for substrates identification and validation, followed by the functional validation in mammalian cells. Specifically, the ... [more]
Int J Mol Sci Jun. 14, 2020; 21(12); [Pubmed: 32545848]
Throughput
- High Throughput
Curated By
- BioGRID