FZD8
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IBA]
- T cell differentiation in thymus [IMP]
- Wnt signaling pathway [IDA]
- angiogenesis [IDA]
- canonical Wnt signaling pathway [IDA, IGI, IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- non-canonical Wnt signaling pathway [IBA]
- positive regulation of JUN kinase activity [IDA]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- signal transduction [IPI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GOPC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled.
The frizzled gene is evolutionally conserved in a wide variety of organisms including mammals, and in Drosophila, frizzled is implicated in the development of planar polarity. We describe here the isolation and characterization of a Golgi protein, GOPC, as a frizzled interacting protein. GOPC comprises one PDZ domain, two coiled-coil motifs and two evolutionally conserved regions. Immunofluorescence studies indicated that ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FZD8 GOPC | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| FZD8 GOPC | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID