FZD5
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IBA]
- Spemann organizer formation [ISO]
- T cell differentiation in thymus [IMP]
- Wnt signaling pathway [IGI]
- Wnt signaling pathway involved in dorsal/ventral axis specification [ISO]
- angiogenesis [IMP]
- anterior/posterior axis specification, embryo [ISO]
- apoptotic process involved in morphogenesis [IMP]
- branching involved in labyrinthine layer morphogenesis [IMP]
- canonical Wnt signaling pathway [IMP, ISO]
- cell maturation [IMP]
- cellular response to molecule of bacterial origin [ISO]
- chorionic trophoblast cell differentiation [IMP]
- embryonic axis specification [ISO]
- embryonic camera-type eye development [IMP]
- labyrinthine layer blood vessel development [IMP]
- negative regulation of cell proliferation [IMP]
- non-canonical Wnt signaling pathway [IBA]
- positive regulation of JUN kinase activity [IDA]
- positive regulation of interferon-gamma production [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- post-embryonic camera-type eye development [IMP]
- regulation of canonical Wnt signaling pathway [IMP]
- regulation of chorionic trophoblast cell proliferation [IMP]
- regulation of tight junction assembly [IMP]
- syncytiotrophoblast cell differentiation involved in labyrinthine layer development [IMP]
- vasculature development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GOPC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled.
The frizzled gene is evolutionally conserved in a wide variety of organisms including mammals, and in Drosophila, frizzled is implicated in the development of planar polarity. We describe here the isolation and characterization of a Golgi protein, GOPC, as a frizzled interacting protein. GOPC comprises one PDZ domain, two coiled-coil motifs and two evolutionally conserved regions. Immunofluorescence studies indicated that ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FZD5 GOPC | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID