BAIT
AGO2
EIF2C2, Q10
argonaute RISC catalytic component 2
GO Process (18)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Notch signaling pathway [TAS]
- RNA phosphodiester bond hydrolysis, endonucleolytic [EXP, IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- gene expression [TAS]
- gene silencing by RNA [ISS]
- innate immune response [TAS]
- mRNA cleavage involved in gene silencing by miRNA [IDA, IMP]
- negative regulation of translation involved in gene silencing by miRNA [IDA, IMP]
- negative regulation of translational initiation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [ISS]
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [ISS]
- pre-miRNA processing [IDA]
- translation [NAS]
- translational initiation [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
KRIT1
CAM, CCM1
KRIT1, ankyrin repeat containing
GO Process (8)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- cell redox homeostasis [IMP]
- negative regulation of angiogenesis [IMP]
- negative regulation of endothelial cell apoptotic process [IMP]
- negative regulation of endothelial cell migration [IMP]
- negative regulation of endothelial cell proliferation [IMP]
- regulation of catalytic activity [TAS]
- regulation of establishment of cell polarity [IMP]
- small GTPase mediated signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Inhibition of Glycolysis in Pathogenic TH17 Cells through Targeting a miR-21-Peli1-c-Rel Pathway Prevents Autoimmunity.
It is well known that some pathogenic cells have enhanced glycolysis; the regulatory network leading to increased glycolysis are not well characterized. In this study, we show that CNS-infiltrated pathogenic TH17 cells from diseased mice specifically upregulate glycolytic pathway genes compared with homeostatic intestinal TH17 cells. Bioenergetic assay and metabolomics analyses indicate that in vitro-derived pathogenic TH17 cells are highly ... [more]
J Immunol Dec. 15, 2019; 204(12);3160-3170 [Pubmed: 32414810]
Throughput
- High Throughput
Additional Notes
- assayed using CLIPseq (cross-link immunoprecipitation and sequencing) in which the bait protein Ago2 was IPd and associated RNA molecules corresponding to the hit genes were identified by sequencing and/or RT-PCR (reverse transcription polymerase chain reaction); other targets were identified but only those that were positive in other assays were reported
Curated By
- BioGRID