BAIT
OGT
HRNT1, O-GLCNAC
O-linked N-acetylglucosamine (GlcNAc) transferase
GO Process (24)
GO Function (9)
GO Component (8)
Gene Ontology Biological Process
- apoptotic process [IDA]
- cellular response to retinoic acid [IMP]
- chromatin organization [TAS]
- circadian regulation of gene expression [ISS]
- histone H3-K4 trimethylation [IMP]
- histone H4-K16 acetylation [IDA]
- histone H4-K5 acetylation [IDA]
- histone H4-K8 acetylation [IDA]
- negative regulation of protein ubiquitination [ISS]
- phosphatidylinositol-mediated signaling [IDA]
- positive regulation of catalytic activity [IDA]
- positive regulation of granulocyte differentiation [IMP]
- positive regulation of histone H3-K27 methylation [IMP]
- positive regulation of histone H3-K4 methylation [IDA]
- positive regulation of proteolysis [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- protein O-linked glycosylation [IDA, IMP]
- regulation of Rac protein signal transduction [IDA]
- regulation of gluconeogenesis involved in cellular glucose homeostasis [ISS]
- regulation of glycolytic process [IDA]
- regulation of insulin receptor signaling pathway [IDA]
- response to insulin [IDA]
- response to nutrient [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function- acetylglucosaminyltransferase activity [TAS]
- enzyme activator activity [IDA]
- histone acetyltransferase activity (H4-K16 specific) [IDA]
- histone acetyltransferase activity (H4-K5 specific) [IDA]
- histone acetyltransferase activity (H4-K8 specific) [IDA]
- phosphatidylinositol-3,4,5-trisphosphate binding [IDA]
- protein N-acetylglucosaminyltransferase activity [IDA]
- protein O-GlcNAc transferase activity [IMP, ISS]
- protein binding [IPI]
- acetylglucosaminyltransferase activity [TAS]
- enzyme activator activity [IDA]
- histone acetyltransferase activity (H4-K16 specific) [IDA]
- histone acetyltransferase activity (H4-K5 specific) [IDA]
- histone acetyltransferase activity (H4-K8 specific) [IDA]
- phosphatidylinositol-3,4,5-trisphosphate binding [IDA]
- protein N-acetylglucosaminyltransferase activity [IDA]
- protein O-GlcNAc transferase activity [IMP, ISS]
- protein binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
SLIT2
SLIL3, Slit-2
slit homolog 2 (Drosophila)
GO Process (37)
GO Function (9)
GO Component (7)
Gene Ontology Biological Process
- Roundabout signaling pathway [IC, IMP]
- apoptotic process involved in luteolysis [IEP]
- axon extension involved in axon guidance [IDA]
- axon guidance [IDA, TAS]
- branching morphogenesis of an epithelial tube [IDA, IMP]
- cell migration involved in sprouting angiogenesis [IMP]
- cellular response to heparin [IDA]
- cellular response to hormone stimulus [IEP]
- chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration [IDA]
- chemorepulsion involved in postnatal olfactory bulb interneuron migration [IDA]
- corticospinal neuron axon guidance through spinal cord [IMP]
- induction of negative chemotaxis [IDA]
- motor neuron axon guidance [IDA]
- negative chemotaxis [IDA, IMP]
- negative regulation of actin filament polymerization [IDA]
- negative regulation of catalytic activity [IDA]
- negative regulation of cell growth [IMP]
- negative regulation of cell migration [IDA, IMP]
- negative regulation of cellular response to growth factor stimulus [IDA]
- negative regulation of chemokine-mediated signaling pathway [IMP]
- negative regulation of endothelial cell migration [IDA]
- negative regulation of lamellipodium assembly [IDA]
- negative regulation of leukocyte chemotaxis [IDA]
- negative regulation of monocyte chemotaxis [ISS]
- negative regulation of mononuclear cell migration [IDA]
- negative regulation of neutrophil chemotaxis [IDA]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of retinal ganglion cell axon guidance [IDA]
- negative regulation of small GTPase mediated signal transduction [IDA]
- negative regulation of smooth muscle cell chemotaxis [IDA]
- negative regulation of smooth muscle cell migration [IDA]
- negative regulation of vascular permeability [IDA]
- positive regulation of apoptotic process [IMP]
- positive regulation of axonogenesis [TAS]
- response to cortisol [IEP]
- retinal ganglion cell axon guidance [IDA]
- ureteric bud development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion.
O-GlcNAc transferase (OGT) is an enzyme that catalyzes the O-GlcNAc modification of nucleocytoplasmic proteins and is highly expressed in many types of cancer. However, the mechanism regulating its expression in cancer cells is not well understood. This study shows that OGT is a substrate of the E3 ubiquitin ligase X-linked inhibitor of apoptosis (XIAP) which plays an important role in ... [more]
Cell Death Dis Dec. 29, 2019; 11(9);815 [Pubmed: 32994395]
Throughput
- High Throughput
Curated By
- BioGRID