BAIT
OGT
HRNT1, O-GLCNAC
O-linked N-acetylglucosamine (GlcNAc) transferase
GO Process (24)
GO Function (9)
GO Component (8)
Gene Ontology Biological Process
- apoptotic process [IDA]
- cellular response to retinoic acid [IMP]
- chromatin organization [TAS]
- circadian regulation of gene expression [ISS]
- histone H3-K4 trimethylation [IMP]
- histone H4-K16 acetylation [IDA]
- histone H4-K5 acetylation [IDA]
- histone H4-K8 acetylation [IDA]
- negative regulation of protein ubiquitination [ISS]
- phosphatidylinositol-mediated signaling [IDA]
- positive regulation of catalytic activity [IDA]
- positive regulation of granulocyte differentiation [IMP]
- positive regulation of histone H3-K27 methylation [IMP]
- positive regulation of histone H3-K4 methylation [IDA]
- positive regulation of proteolysis [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- protein O-linked glycosylation [IDA, IMP]
- regulation of Rac protein signal transduction [IDA]
- regulation of gluconeogenesis involved in cellular glucose homeostasis [ISS]
- regulation of glycolytic process [IDA]
- regulation of insulin receptor signaling pathway [IDA]
- response to insulin [IDA]
- response to nutrient [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function- acetylglucosaminyltransferase activity [TAS]
- enzyme activator activity [IDA]
- histone acetyltransferase activity (H4-K16 specific) [IDA]
- histone acetyltransferase activity (H4-K5 specific) [IDA]
- histone acetyltransferase activity (H4-K8 specific) [IDA]
- phosphatidylinositol-3,4,5-trisphosphate binding [IDA]
- protein N-acetylglucosaminyltransferase activity [IDA]
- protein O-GlcNAc transferase activity [IMP, ISS]
- protein binding [IPI]
- acetylglucosaminyltransferase activity [TAS]
- enzyme activator activity [IDA]
- histone acetyltransferase activity (H4-K16 specific) [IDA]
- histone acetyltransferase activity (H4-K5 specific) [IDA]
- histone acetyltransferase activity (H4-K8 specific) [IDA]
- phosphatidylinositol-3,4,5-trisphosphate binding [IDA]
- protein N-acetylglucosaminyltransferase activity [IDA]
- protein O-GlcNAc transferase activity [IMP, ISS]
- protein binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
CASP8
ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5
caspase 8, apoptosis-related cysteine peptidase
GO Process (33)
GO Function (9)
GO Component (10)
Gene Ontology Biological Process
- B cell activation [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- T cell activation [TAS]
- TRAIL-activated apoptotic signaling pathway [IDA]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of cysteine-type endopeptidase activity [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
- apoptotic process [IGI, IMP, TAS]
- apoptotic signaling pathway [IMP, TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular response to mechanical stimulus [IEP]
- execution phase of apoptosis [IMP]
- extrinsic apoptotic signaling pathway [IDA]
- extrinsic apoptotic signaling pathway via death domain receptors [IBA]
- innate immune response [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- macrophage differentiation [TAS]
- natural killer cell activation [TAS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway [TAS]
- nucleotide-binding oligomerization domain containing signaling pathway [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP, IMP]
- positive regulation of macrophage differentiation [IMP]
- positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway [TAS]
- positive regulation of proteolysis [IDA]
- proteolysis [IDA]
- proteolysis involved in cellular protein catabolic process [IMP]
- regulation of extrinsic apoptotic signaling pathway in absence of ligand [TAS]
- response to tumor necrosis factor [IMP]
- syncytiotrophoblast cell differentiation involved in labyrinthine layer development [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function- cysteine-type endopeptidase activity [IDA, TAS]
- cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- cysteine-type endopeptidase activity involved in apoptotic signaling pathway [IMP]
- cysteine-type peptidase activity [TAS]
- death effector domain binding [IPI]
- peptidase activity [IMP]
- protein binding [IPI]
- scaffold protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
- cysteine-type endopeptidase activity [IDA, TAS]
- cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- cysteine-type endopeptidase activity involved in apoptotic signaling pathway [IMP]
- cysteine-type peptidase activity [TAS]
- death effector domain binding [IPI]
- peptidase activity [IMP]
- protein binding [IPI]
- scaffold protein binding [IPI]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion.
O-GlcNAc transferase (OGT) is an enzyme that catalyzes the O-GlcNAc modification of nucleocytoplasmic proteins and is highly expressed in many types of cancer. However, the mechanism regulating its expression in cancer cells is not well understood. This study shows that OGT is a substrate of the E3 ubiquitin ligase X-linked inhibitor of apoptosis (XIAP) which plays an important role in ... [more]
Cell Death Dis Dec. 29, 2019; 11(9);815 [Pubmed: 32994395]
Throughput
- High Throughput
Curated By
- BioGRID