BAIT
FBXO6
FBG2, FBS2, FBX6, Fbx6b, RP3-330O12.3
F-box protein 6
GO Process (5)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ABCD1
ABC42, ALD, ALDP, AMN
ATP-binding cassette, sub-family D (ALD), member 1
GO Process (14)
GO Function (9)
GO Component (7)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- alpha-linolenic acid metabolic process [TAS]
- cellular lipid metabolic process [TAS]
- fatty acid beta-oxidation [IDA, IGI]
- fatty acid beta-oxidation using acyl-CoA oxidase [TAS]
- linoleic acid metabolic process [TAS]
- long-chain fatty acid catabolic process [IGI]
- peroxisomal long-chain fatty acid import [IGI]
- peroxisomal membrane transport [NAS]
- peroxisome organization [IDA, NAS]
- small molecule metabolic process [TAS]
- transmembrane transport [TAS]
- unsaturated fatty acid metabolic process [TAS]
- very long-chain fatty acid catabolic process [IDA, IGI]
Gene Ontology Molecular Function- ATP binding [IDA]
- ATPase activity [IDA]
- ATPase activity, coupled to transmembrane movement of substances [NAS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- peroxisomal fatty-acyl-CoA transporter activity [IGI, TAS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- transporter activity [NAS]
- ATP binding [IDA]
- ATPase activity [IDA]
- ATPase activity, coupled to transmembrane movement of substances [NAS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- peroxisomal fatty-acyl-CoA transporter activity [IGI, TAS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- transporter activity [NAS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TGF? attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.
FBXO6, a component of the ubiquitin E3 ligases, has been shown to bind high mannose N-linked glycoproteins and act as ubiquitin ligase subunits. Most proteins in the secretory pathway, such as matrix metalloproteinases, are modified with N-glycans and play important roles in the development of osteoarthritis (OA). However, whether FBXO6 exerts regulatory effects on the pathogenesis of OA remains undefined.The ... [more]
Ann Rheum Dis Dec. 01, 2019; 79(8);1111-1120 [Pubmed: 32409323]
Throughput
- High Throughput
Curated By
- BioGRID